Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of down syndrome

Jisook Moon, May Chen, Shruti U. Gandhy, Myla Strawderman, David A. Levitsky, Kenneth N. Maclean, Barbara J. Strupp

Research output: Contribution to journalArticle

Abstract

In addition to mental retardation, individuals with Down syndrome (DS) also develop the neuropathological changes typical of Alzheimer's disease (AD) and the majority of these individuals exhibit dementia. The Ts65Dn mouse model of DS exhibits key features of these disorders, including early degeneration of cholinergic basal forebrain (CBF) neurons and impairments in functions dependent on the two CBF projection systems; namely, attention and explicit memory. Herein, we demonstrate that supplementing the maternal diet with excess choline during pregnancy and lactation dramatically improved attentional function of the adult trisomic offspring. Specifically, the adult offspring of choline-supplemented Ts65Dn dams performed significantly better than unsupplemented Ts65Dn mice on a series of 5 visual attention tasks, and in fact, on some tasks did not differ from the normosomic (2N) controls. A second area of dysfunction in the trisomic animals, heightened reactivity to committing an error, was partially normalized by the early choline supplementation. The 2N littermates also benefited from increased maternal choline intake on 1 attention task. These findings collectively suggest that perinatal choline supplementation might significantly lessen cognitive dysfunction in DS and reduce cognitive decline in related neurodegenerative disorders such as AD.

Original languageEnglish (US)
Pages (from-to)346-361
Number of pages16
JournalBehavioral Neuroscience
Volume124
Issue number3
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Down Syndrome
Choline
Emotions
Cholinergic Agents
Alzheimer Disease
Mothers
Lactation
Intellectual Disability
Neurodegenerative Diseases
Dementia
Diet
Neurons
Pregnancy
Cognitive Dysfunction
Basal Forebrain

Keywords

  • Alzheimer's disease
  • Arousal
  • Attention
  • Choline-early exposure delayed effects
  • Down syndrome

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Medicine(all)

Cite this

Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of down syndrome. / Moon, Jisook; Chen, May; Gandhy, Shruti U.; Strawderman, Myla; Levitsky, David A.; Maclean, Kenneth N.; Strupp, Barbara J.

In: Behavioral Neuroscience, Vol. 124, No. 3, 01.01.2010, p. 346-361.

Research output: Contribution to journalArticle

Moon, Jisook ; Chen, May ; Gandhy, Shruti U. ; Strawderman, Myla ; Levitsky, David A. ; Maclean, Kenneth N. ; Strupp, Barbara J. / Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of down syndrome. In: Behavioral Neuroscience. 2010 ; Vol. 124, No. 3. pp. 346-361.
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