Perinatal Brain Injury: Mechanisms, Prevention, and Outcomes

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Abstract

Perinatal brain injury may lead to long-term morbidity and neurodevelopmental impairment. Improvements in perinatal care have resulted in the survival of more infants with perinatal brain injury. The effects of hypoxia–ischemia, inflammation, and infection during critical periods of development can lead to a common pathway of perinatal brain injury marked by neuronal excitotoxicity, cellular apoptosis, and microglial activation. Various interventions can prevent or improve the outcomes of different types of perinatal brain injury. The objective of this article is to review the mechanisms of perinatal brain injury, approaches to prevention, and outcomes among children with perinatal brain injury.

Original languageEnglish (US)
JournalClinics in Perinatology
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Keywords

  • Cerebral palsy
  • Encephalopathy
  • Hypothermia
  • Intraventricular hemorrhage
  • Perinatal arterial ischemic stroke
  • Perinatal brain injury
  • Periventricular leukomalacia
  • Prevention

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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