Perinatal Brain Injury: Mechanisms, Prevention, and Outcomes

Christopher Novak; Maide Ozen; Irina Burd

doi:10.1016/j.clp.2018.01.015

Perinatal Brain Injury: Mechanisms, Prevention, and Outcomes

Christopher Novak, Maide Ozen, Irina Burd

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Perinatal brain injury may lead to long-term morbidity and neurodevelopmental impairment. Improvements in perinatal care have resulted in the survival of more infants with perinatal brain injury. The effects of hypoxia–ischemia, inflammation, and infection during critical periods of development can lead to a common pathway of perinatal brain injury marked by neuronal excitotoxicity, cellular apoptosis, and microglial activation. Various interventions can prevent or improve the outcomes of different types of perinatal brain injury. The objective of this article is to review the mechanisms of perinatal brain injury, approaches to prevention, and outcomes among children with perinatal brain injury.

Original language	English (US)
Journal	Clinics in Perinatology
DOIs	https://doi.org/10.1016/j.clp.2018.01.015
State	Accepted/In press - Jan 1 2018

Keywords

Cerebral palsy
Encephalopathy
Hypothermia
Intraventricular hemorrhage
Perinatal arterial ischemic stroke
Perinatal brain injury
Periventricular leukomalacia
Prevention

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1016/j.clp.2018.01.015

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title = "Perinatal Brain Injury: Mechanisms, Prevention, and Outcomes",

abstract = "Perinatal brain injury may lead to long-term morbidity and neurodevelopmental impairment. Improvements in perinatal care have resulted in the survival of more infants with perinatal brain injury. The effects of hypoxia–ischemia, inflammation, and infection during critical periods of development can lead to a common pathway of perinatal brain injury marked by neuronal excitotoxicity, cellular apoptosis, and microglial activation. Various interventions can prevent or improve the outcomes of different types of perinatal brain injury. The objective of this article is to review the mechanisms of perinatal brain injury, approaches to prevention, and outcomes among children with perinatal brain injury.",

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AU - Burd, Irina

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KW - Perinatal brain injury

KW - Periventricular leukomalacia

KW - Prevention

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Perinatal Brain Injury: Mechanisms, Prevention, and Outcomes

Abstract

Keywords

ASJC Scopus subject areas

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