Perinatal biomarkers in prematurity: Early identification of neurologic injury

Maria Andrikopoulou, Ahmad Almalki, Azadeh Farzin, Christina N. Cordeiro, Michael V. Johnston, Irina Burd

Research output: Contribution to journalReview article

Abstract

Over the past few decades, biomarkers have become increasingly utilized as non-invasive tools in the early diagnosis and management of various clinical conditions. In perinatal medicine, the improved survival of extremely premature infants who are at high risk for adverse neurologic outcomes has increased the demand for the discovery of biomarkers in detecting and predicting the prognosis of infants with neonatal brain injury. By enabling the clinician to recognize potential brain damage early, biomarkers could allow clinicians to intervene at the early stages of disease, and to monitor the efficacy of those interventions. This review will first examine the potential perinatal biomarkers for neurologic complications of prematurity, specifically, intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL) and posthemorrhagic hydrocephalus (PHH). It will also evaluate knowledge gained from animal models regarding the pathogenesis of perinatal brain injury in prematurity.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalInternational Journal of Developmental Neuroscience
Volume36
DOIs
StatePublished - Aug 2014

Keywords

  • Biomarkers
  • Brain injury
  • Intraventricular hemorrhage
  • Periventricular leukomalacia
  • Prematurity

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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