Perikaryal RNA changes within neurons of the caudate-putamen and substantia nigra in soman intoxicated rats

Lee J Martin, J. A. Doebler, A. Anthony

Research output: Contribution to journalArticle

Abstract

Quantitative azure B cytophotometry was employed to monitor neuronal ribonucleic acid (RNA) metabolism within cholinergic and noncholinergic brain compartments following single sc injections of either 0.5, 0.9 or 1.5 LD50 soman (pinacolyl methylphosphonofluoridate). Dose-dependent losses in neuronal RNA were observed within the cholinergic caudate-putamen (CP) and dopaminergic substantia nigra pars compacta (SNPC), whereas levels of RNA were generally maintained or elevated within the gabaergic substantia nigra pars reticulata (SNPR). CP acetylcholinesterase was inhibited in a dose-dependent fashion. These neuronal RNA changes are perhaps related to seizure activity. The overall data lend support to the hypothesis that alterations in noncholinergic activity contribute to certain manifestations of soman neurotoxicity, such as seizures, which probably stem from an impairment in the functional integrity of both excitatory and inhibitory neuronal elements.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalNeurochemistry International
Volume9
Issue number1
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Soman
Putamen
Substantia Nigra
RNA
Neurons
Cholinergic Agents
Seizures
Cytophotometry
Lethal Dose 50
Acetylcholinesterase
Injections
Brain

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Perikaryal RNA changes within neurons of the caudate-putamen and substantia nigra in soman intoxicated rats. / Martin, Lee J; Doebler, J. A.; Anthony, A.

In: Neurochemistry International, Vol. 9, No. 1, 1986, p. 121-126.

Research output: Contribution to journalArticle

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