Pericytes in sarcomas of bone

Le Chang, Vi Nguyen, Alan Nguyen, Michelle A. Scott, Aaron W. James

Research output: Contribution to journalReview articlepeer-review

Abstract

Pericytes are mesenchymal cells that closely enwrap small blood vessels, lying in intimate association with the endothelium. Pericytes have recently gained attention as an important mediator of vascular biology and angiogenesis in cancer. Although better studied in carcinoma, pericytes have known interaction with sarcomas of bone, including Ewing’s sarcoma, osteosarcoma, and chondrosarcoma. Best studied is Ewing’s sarcoma (ES), which displays a prominent perivascular growth pattern. Signaling pathways of known importance in intratumoral pericytes in ES include Notch, PDGF/PDGFR-β, and VEGF signaling. In summary, pericytes serve important functions in the tumor microenvironment. Improved understanding of pericyte biology may hold significant implications for the development of new therapies in sarcoma.

Original languageEnglish (US)
Article number202
JournalMedical Oncology
Volume32
Issue number7
DOIs
StatePublished - Jul 17 2015
Externally publishedYes

Keywords

  • Chondrosarcoma
  • Ewing’s sarcoma
  • Notch pathway
  • Osteosarcoma
  • PDGF
  • Pericyte
  • Platelet-derived growth factor beta
  • VEGF
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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