Pericytes for therapeutic bone repair

Carolyn A. Meyers, Joan Casamitjana, Leslie Chang, Lei Zhang, Aaron James, Bruno Péault

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Besides seminal functions in angiogenesis and blood pressure regulation, microvascular pericytes possess a latent tissue regenerative potential that can be revealed in culture following transition into mesenchymal stem cells. Endowed with robust osteogenic potential, pericytes and other related perivascular cells extracted from adipose tissue represent a potent and abundant cell source for refined bone tissue engineering and improved cell therapies of fractures and other bone defects. The use of diverse bone formation assays in vivo, which include mouse muscle pocket osteogenesis and calvaria replenishment, rat and dog spine fusion, and rat non-union fracture healing, has confirmed the superiority of purified perivascular cells for skeletal (re)generation. As a surprising observation though, despite strong endogenous bone-forming potential, perivascular cells drive bone regeneration essentially indirectly, via recruitment by secreted factors of local osteo-progenitors.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages21-32
Number of pages12
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1109
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Blood vessel
  • Bone
  • Mesenchymal stem cell
  • Non-union
  • Osteogenesis
  • Pericyte
  • Perivascular cell
  • Spinal fusion
  • Stem cell
  • Tunica adventitia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Meyers, C. A., Casamitjana, J., Chang, L., Zhang, L., James, A., & Péault, B. (2018). Pericytes for therapeutic bone repair. In Advances in Experimental Medicine and Biology (pp. 21-32). (Advances in Experimental Medicine and Biology; Vol. 1109). Springer New York LLC. https://doi.org/10.1007/978-3-030-02601-1_3