Pericardial adipose tissue and coronary artery calcification in the Multi-ethnic Study of Atherosclerosis (MESA)

Jill McClain, Fang Hsu, Elizabeth Brown, Gregory Burke, John Carr, Tamara Harris, Stephen Kritchevsky, Moyses Szklo, Russell Tracy, Jingzhong Ding

Research output: Contribution to journalArticle

Abstract

Objective: To examine the relationship of pericardial adipose tissue (PAT) with coronary artery calcification in the Multi-Ethnic Study of Atherosclerosis. Design and Methods: The baseline cohort comprised 6,814 Caucasian (38%), African-American (28%), Chinese American (12%), and Hispanic (22%) adults aged 45-84, without known clinical cardiovascular disease. Cardiac CT was used to measure PAT (cm3) and calcification (Agatston score). We examined cross-sectional associations of PAT with the presence (score >0) and severity (continuous score if >0) of calcification using prevalence ratio (PR) (n = 6,672) and linear regression (n = 3,362), respectively. Main models were adjusted for age, age2, gender, race/ethnicity, field site, smoking, physical activity, alcohol, and education. Results: PAT volume (adjusted for age, height, weight, and site) was greatest in Chinese males, whereas Black males had less PAT than all but Black females. PAT was associated with presence [PR per standard deviation (SD): 1.06 (95% CI: 1.04, 1.08)] and severity [difference in log Agatston score per SD: 0.15 (0.09, 0.21)] of calcification, but neither association varied by race/ethnicity. Adjustment for generalized adiposity attenuated but did not eliminate the associations. With further adjustment for traditional risk factors and inflammatory markers, only the association with severity remained statistically significant [PR: 1.02 (1.00, 1.04); difference: 0.10 (0.03, 0.17)]. Heterogeneity by sex was observed for the presence of calcification (PR in men: 1.04; in women: 1.08; P for interaction

Original languageEnglish (US)
Pages (from-to)1056-1063
Number of pages8
JournalObesity
Volume21
Issue number5
DOIs
StatePublished - May 2013

Fingerprint

Adipose Tissue
Atherosclerosis
Coronary Vessels
Physical Education and Training
Asian Americans
Adiposity
Hispanic Americans
African Americans
Linear Models
Cardiovascular Diseases
Smoking
Alcohols
Exercise
Weights and Measures

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

McClain, J., Hsu, F., Brown, E., Burke, G., Carr, J., Harris, T., ... Ding, J. (2013). Pericardial adipose tissue and coronary artery calcification in the Multi-ethnic Study of Atherosclerosis (MESA). Obesity, 21(5), 1056-1063. https://doi.org/10.1002/oby.20090

Pericardial adipose tissue and coronary artery calcification in the Multi-ethnic Study of Atherosclerosis (MESA). / McClain, Jill; Hsu, Fang; Brown, Elizabeth; Burke, Gregory; Carr, John; Harris, Tamara; Kritchevsky, Stephen; Szklo, Moyses; Tracy, Russell; Ding, Jingzhong.

In: Obesity, Vol. 21, No. 5, 05.2013, p. 1056-1063.

Research output: Contribution to journalArticle

McClain, J, Hsu, F, Brown, E, Burke, G, Carr, J, Harris, T, Kritchevsky, S, Szklo, M, Tracy, R & Ding, J 2013, 'Pericardial adipose tissue and coronary artery calcification in the Multi-ethnic Study of Atherosclerosis (MESA)', Obesity, vol. 21, no. 5, pp. 1056-1063. https://doi.org/10.1002/oby.20090
McClain, Jill ; Hsu, Fang ; Brown, Elizabeth ; Burke, Gregory ; Carr, John ; Harris, Tamara ; Kritchevsky, Stephen ; Szklo, Moyses ; Tracy, Russell ; Ding, Jingzhong. / Pericardial adipose tissue and coronary artery calcification in the Multi-ethnic Study of Atherosclerosis (MESA). In: Obesity. 2013 ; Vol. 21, No. 5. pp. 1056-1063.
@article{62afab78b4ab44a0929bd9416c6ae645,
title = "Pericardial adipose tissue and coronary artery calcification in the Multi-ethnic Study of Atherosclerosis (MESA)",
abstract = "Objective: To examine the relationship of pericardial adipose tissue (PAT) with coronary artery calcification in the Multi-Ethnic Study of Atherosclerosis. Design and Methods: The baseline cohort comprised 6,814 Caucasian (38{\%}), African-American (28{\%}), Chinese American (12{\%}), and Hispanic (22{\%}) adults aged 45-84, without known clinical cardiovascular disease. Cardiac CT was used to measure PAT (cm3) and calcification (Agatston score). We examined cross-sectional associations of PAT with the presence (score >0) and severity (continuous score if >0) of calcification using prevalence ratio (PR) (n = 6,672) and linear regression (n = 3,362), respectively. Main models were adjusted for age, age2, gender, race/ethnicity, field site, smoking, physical activity, alcohol, and education. Results: PAT volume (adjusted for age, height, weight, and site) was greatest in Chinese males, whereas Black males had less PAT than all but Black females. PAT was associated with presence [PR per standard deviation (SD): 1.06 (95{\%} CI: 1.04, 1.08)] and severity [difference in log Agatston score per SD: 0.15 (0.09, 0.21)] of calcification, but neither association varied by race/ethnicity. Adjustment for generalized adiposity attenuated but did not eliminate the associations. With further adjustment for traditional risk factors and inflammatory markers, only the association with severity remained statistically significant [PR: 1.02 (1.00, 1.04); difference: 0.10 (0.03, 0.17)]. Heterogeneity by sex was observed for the presence of calcification (PR in men: 1.04; in women: 1.08; P for interaction",
author = "Jill McClain and Fang Hsu and Elizabeth Brown and Gregory Burke and John Carr and Tamara Harris and Stephen Kritchevsky and Moyses Szklo and Russell Tracy and Jingzhong Ding",
year = "2013",
month = "5",
doi = "10.1002/oby.20090",
language = "English (US)",
volume = "21",
pages = "1056--1063",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Pericardial adipose tissue and coronary artery calcification in the Multi-ethnic Study of Atherosclerosis (MESA)

AU - McClain, Jill

AU - Hsu, Fang

AU - Brown, Elizabeth

AU - Burke, Gregory

AU - Carr, John

AU - Harris, Tamara

AU - Kritchevsky, Stephen

AU - Szklo, Moyses

AU - Tracy, Russell

AU - Ding, Jingzhong

PY - 2013/5

Y1 - 2013/5

N2 - Objective: To examine the relationship of pericardial adipose tissue (PAT) with coronary artery calcification in the Multi-Ethnic Study of Atherosclerosis. Design and Methods: The baseline cohort comprised 6,814 Caucasian (38%), African-American (28%), Chinese American (12%), and Hispanic (22%) adults aged 45-84, without known clinical cardiovascular disease. Cardiac CT was used to measure PAT (cm3) and calcification (Agatston score). We examined cross-sectional associations of PAT with the presence (score >0) and severity (continuous score if >0) of calcification using prevalence ratio (PR) (n = 6,672) and linear regression (n = 3,362), respectively. Main models were adjusted for age, age2, gender, race/ethnicity, field site, smoking, physical activity, alcohol, and education. Results: PAT volume (adjusted for age, height, weight, and site) was greatest in Chinese males, whereas Black males had less PAT than all but Black females. PAT was associated with presence [PR per standard deviation (SD): 1.06 (95% CI: 1.04, 1.08)] and severity [difference in log Agatston score per SD: 0.15 (0.09, 0.21)] of calcification, but neither association varied by race/ethnicity. Adjustment for generalized adiposity attenuated but did not eliminate the associations. With further adjustment for traditional risk factors and inflammatory markers, only the association with severity remained statistically significant [PR: 1.02 (1.00, 1.04); difference: 0.10 (0.03, 0.17)]. Heterogeneity by sex was observed for the presence of calcification (PR in men: 1.04; in women: 1.08; P for interaction

AB - Objective: To examine the relationship of pericardial adipose tissue (PAT) with coronary artery calcification in the Multi-Ethnic Study of Atherosclerosis. Design and Methods: The baseline cohort comprised 6,814 Caucasian (38%), African-American (28%), Chinese American (12%), and Hispanic (22%) adults aged 45-84, without known clinical cardiovascular disease. Cardiac CT was used to measure PAT (cm3) and calcification (Agatston score). We examined cross-sectional associations of PAT with the presence (score >0) and severity (continuous score if >0) of calcification using prevalence ratio (PR) (n = 6,672) and linear regression (n = 3,362), respectively. Main models were adjusted for age, age2, gender, race/ethnicity, field site, smoking, physical activity, alcohol, and education. Results: PAT volume (adjusted for age, height, weight, and site) was greatest in Chinese males, whereas Black males had less PAT than all but Black females. PAT was associated with presence [PR per standard deviation (SD): 1.06 (95% CI: 1.04, 1.08)] and severity [difference in log Agatston score per SD: 0.15 (0.09, 0.21)] of calcification, but neither association varied by race/ethnicity. Adjustment for generalized adiposity attenuated but did not eliminate the associations. With further adjustment for traditional risk factors and inflammatory markers, only the association with severity remained statistically significant [PR: 1.02 (1.00, 1.04); difference: 0.10 (0.03, 0.17)]. Heterogeneity by sex was observed for the presence of calcification (PR in men: 1.04; in women: 1.08; P for interaction

UR - http://www.scopus.com/inward/record.url?scp=84879400362&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879400362&partnerID=8YFLogxK

U2 - 10.1002/oby.20090

DO - 10.1002/oby.20090

M3 - Article

VL - 21

SP - 1056

EP - 1063

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 5

ER -