Peri-Implantation Hormonal Milieu: Elucidating Mechanisms of Adverse Neurodevelopmental Outcomes

Monica Mainigi, Jason M. Rosenzweig, Jun Lei, Virginia Mensah, Lauren Thomaier, C. Conover Talbot, Devvora Olalere, Teri Ord, Rayyan Rozzah, Michael V Johnston, Irina Burd

Research output: Contribution to journalArticle

Abstract

While live births resulting from assisted reproductive technology (ART) exceed 1% of total births annually, the effect of ART on fetal development is not well understood. Data have demonstrated that IVF leads to alterations in DNA methylation and gene expression in the placenta that may have long-term effects on health and disease. Studies have linked adverse neurodevelopmental outcomes to ART, although human studies are inconclusive. In order to isolate the peri-implantation environment and its effects on brain development, we utilized a mouse model with and without superovulation and examined the effect of adult behavior as well as adult cortical neuronal density. Adult offspring of superovulated dams showed increased anxiety-like behavior compared to offspring of naturally mated dams (P

Original languageEnglish (US)
Pages (from-to)785-794
Number of pages10
JournalReproductive Sciences
Volume23
Issue number6
DOIs
StatePublished - 2015

Keywords

  • ART
  • epigenetics
  • IVF
  • neurodevelopment
  • neuronal differentiation
  • superovulation

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Peri-Implantation Hormonal Milieu: Elucidating Mechanisms of Adverse Neurodevelopmental Outcomes'. Together they form a unique fingerprint.

  • Cite this

    Mainigi, M., Rosenzweig, J. M., Lei, J., Mensah, V., Thomaier, L., Talbot, C. C., Olalere, D., Ord, T., Rozzah, R., Johnston, M. V., & Burd, I. (2015). Peri-Implantation Hormonal Milieu: Elucidating Mechanisms of Adverse Neurodevelopmental Outcomes. Reproductive Sciences, 23(6), 785-794. https://doi.org/10.1177/1933719115618280