Perfusion nephropathy in human transplants

D. Spector, C. Limas, J. L. Frost, J. B. Zachary, S. Sterioff, G. M. Williams, R. T. Rolley, J. H. Sadler

Research output: Contribution to journalArticle

Abstract

To determine whether perfusion preservation affected the structure and survival of kidney transplants, the clinical and histologic data in 77 kidneys biopsied 1 hr after transplantation were compared. Out of 36 perfusion preserved kidneys 21 had a glomerular capillary lesion suggestive of intravascular coagulation. None of 41 kidneys preserved by hypothermia alone had this lesion. Presence of the lesion did not correlate with donor or recipient characteristics, warm or cold ischemia time, HLA match, percentage of preformed lymphocytotoxic antibody titers or perfusion characteristics. Of 21 transplants with the lesion, 9 required nephrectomy by 1 mth, and 1 mth serum creatinine was less than 2.0 mg per deciliter in only 3 of the remaining 12 transplants. It is concluded that perfusion preservation may cause pathologic changes that may adversely affect kidney transplant function. The causes of the pathologic process remain unclear.

Original languageEnglish (US)
Pages (from-to)1217-1221
Number of pages5
JournalNew England Journal of Medicine
Volume295
Issue number22
StatePublished - 1976

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Perfusion
Transplants
Kidney
Cold Ischemia
Warm Ischemia
Antilymphocyte Serum
Pathologic Processes
Hypothermia
Nephrectomy
Creatinine
Transplantation
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Spector, D., Limas, C., Frost, J. L., Zachary, J. B., Sterioff, S., Williams, G. M., ... Sadler, J. H. (1976). Perfusion nephropathy in human transplants. New England Journal of Medicine, 295(22), 1217-1221.

Perfusion nephropathy in human transplants. / Spector, D.; Limas, C.; Frost, J. L.; Zachary, J. B.; Sterioff, S.; Williams, G. M.; Rolley, R. T.; Sadler, J. H.

In: New England Journal of Medicine, Vol. 295, No. 22, 1976, p. 1217-1221.

Research output: Contribution to journalArticle

Spector, D, Limas, C, Frost, JL, Zachary, JB, Sterioff, S, Williams, GM, Rolley, RT & Sadler, JH 1976, 'Perfusion nephropathy in human transplants', New England Journal of Medicine, vol. 295, no. 22, pp. 1217-1221.
Spector D, Limas C, Frost JL, Zachary JB, Sterioff S, Williams GM et al. Perfusion nephropathy in human transplants. New England Journal of Medicine. 1976;295(22):1217-1221.
Spector, D. ; Limas, C. ; Frost, J. L. ; Zachary, J. B. ; Sterioff, S. ; Williams, G. M. ; Rolley, R. T. ; Sadler, J. H. / Perfusion nephropathy in human transplants. In: New England Journal of Medicine. 1976 ; Vol. 295, No. 22. pp. 1217-1221.
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