Perfusion imaging of the human brain at 1.5 T using a single-shot EPI spin tagging approach

Frank Q. Ye, James J Pekar, Peter Jezzard, Jeff Duyn, Joseph A. Frank, Alan C. McLaughlin

Research output: Contribution to journalArticle

Abstract

Single-shot echo planar imaging (EPI) techniques have been applied, in conjunction with arterial spin tagging approaches, to obtain images of cerebral blood flow in a single axial slice in the human brain. Serial studies demonstrate that cerebral blood flow images acquired in 8 min are reproducible, with a statistical precision of approximately ±10 cc/100 g/min. The average value of cerebral blood flow in the slice is 51 ± 11 cc/100 g/min for six normal subjects. The cerebral blood flow images contain two types of artifact, probably due to arterial and venous blood volume contributions, which must be overcome before the arterial spin tagging approach can be used for routine clinical studies.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalMagnetic Resonance in Medicine
Volume36
Issue number2
Publication statusPublished - Aug 1996
Externally publishedYes

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Keywords

  • brain
  • cerebral blood flow
  • human
  • perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Ye, F. Q., Pekar, J. J., Jezzard, P., Duyn, J., Frank, J. A., & McLaughlin, A. C. (1996). Perfusion imaging of the human brain at 1.5 T using a single-shot EPI spin tagging approach. Magnetic Resonance in Medicine, 36(2), 219-224.