Perfusion deficits in patients with mild traumatic brain injury characterized by dynamic susceptibility contrast MRI

Wei Liu, Binquan Wang, Rachel Wolfowitz, Ping Hong Yeh, Dominic E. Nathan, John Graner, Haiying Tang, Hai Pan, Jamie Harper, Dzung Pham, Terrence R. Oakes, Louis M. French, Gerard Riedy

Research output: Contribution to journalArticle

Abstract

Perfusion deficits in patients with mild traumatic brain injury (TBI) from a military population were characterized by dynamic susceptibility contrast perfusion imaging. Relative cerebral blood flow (rCBF) was calculated by a model-independent deconvolution approach from the tracer concentration curves following a bolus injection of gadolinium diethylenetriaminepentaacetate (Gd-DTPA) using both manually and automatically selected arterial input functions (AIFs). Linear regression analysis of the mean values of rCBF from selected regions of interest showed a very good agreement between the two approaches, with a regression coefficient of R=0.88 and a slope of 0.88. The Bland-Altman plot also illustrated the good agreement between the two approaches, with a mean difference of 0.6±12.4mL/100g/min. Voxelwise analysis of rCBF maps from both approaches demonstrated multiple clusters of decreased perfusion (p

Original languageEnglish (US)
Pages (from-to)651-663
Number of pages13
JournalNMR in Biomedicine
Volume26
Issue number6
DOIs
StatePublished - Jun 2013
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Brain Concussion
Magnetic resonance imaging
Brain
Blood
Perfusion
Perfusion Imaging
Gadolinium
Deconvolution
Linear regression
Regression analysis
Linear Models
Regression Analysis
Imaging techniques
Injections
Population

Keywords

  • Arterial input function
  • Dynamic susceptibility-weighted MRI
  • Perfusion
  • Relative cerebral flood flow
  • Traumatic brain injury

ASJC Scopus subject areas

  • Spectroscopy
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Liu, W., Wang, B., Wolfowitz, R., Yeh, P. H., Nathan, D. E., Graner, J., ... Riedy, G. (2013). Perfusion deficits in patients with mild traumatic brain injury characterized by dynamic susceptibility contrast MRI. NMR in Biomedicine, 26(6), 651-663. https://doi.org/10.1002/nbm.2910

Perfusion deficits in patients with mild traumatic brain injury characterized by dynamic susceptibility contrast MRI. / Liu, Wei; Wang, Binquan; Wolfowitz, Rachel; Yeh, Ping Hong; Nathan, Dominic E.; Graner, John; Tang, Haiying; Pan, Hai; Harper, Jamie; Pham, Dzung; Oakes, Terrence R.; French, Louis M.; Riedy, Gerard.

In: NMR in Biomedicine, Vol. 26, No. 6, 06.2013, p. 651-663.

Research output: Contribution to journalArticle

Liu, W, Wang, B, Wolfowitz, R, Yeh, PH, Nathan, DE, Graner, J, Tang, H, Pan, H, Harper, J, Pham, D, Oakes, TR, French, LM & Riedy, G 2013, 'Perfusion deficits in patients with mild traumatic brain injury characterized by dynamic susceptibility contrast MRI', NMR in Biomedicine, vol. 26, no. 6, pp. 651-663. https://doi.org/10.1002/nbm.2910
Liu, Wei ; Wang, Binquan ; Wolfowitz, Rachel ; Yeh, Ping Hong ; Nathan, Dominic E. ; Graner, John ; Tang, Haiying ; Pan, Hai ; Harper, Jamie ; Pham, Dzung ; Oakes, Terrence R. ; French, Louis M. ; Riedy, Gerard. / Perfusion deficits in patients with mild traumatic brain injury characterized by dynamic susceptibility contrast MRI. In: NMR in Biomedicine. 2013 ; Vol. 26, No. 6. pp. 651-663.
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