Perfusion Damage to Renal Allografts

Donald R. Steinmuller, Charles P. Tifft, John J. Curtis, Dinyar Bhathena, Bruce A. Lucas, J. William Mcroberts, Robert G. Luke, David Spector, Catherine Limas, James L. Frost, James B. Zachary, Sylvester Sterioff, G. Melville Williams, Ronald T. Rolley, John H. Sadler

Research output: Contribution to journalLetterpeer-review

Abstract

To the Editor: The perfusion nephropathy in human transplants described by Spector et al. (N Engl J Med 295:1217–1221, 1976) is morphologically very similar to the glomerular lesion attributed to steroids in canine homografts and autografts.1,2 Both have diffuse eosinophilic material within glomerular loops and a similar appearance on light microscopy at one to two hours. Since methylprednisolone (120 mg) was added to the perfusate in all the perfused donor kidneys reported by Spector and his colleagues, it is possible that this agent was responsible for the pathologic lesion and the decreased graft survival. The dose of methylprednisolone in.

Original languageEnglish (US)
Pages (from-to)1232-1233
Number of pages2
JournalNew England Journal of Medicine
Volume296
Issue number21
DOIs
StatePublished - May 26 1977

ASJC Scopus subject areas

  • Medicine(all)

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