Abstract
Sixteen human volunteers with little or no experience using tobacco participated in one 4.5-h experimental session in which they were administered three doses of nicotine polacrilex gum (0, 2 and 4 mg) in ascending order at 90-min intervals. Physiological, subjective, and cognitive performance measures were assessed before and after each dose. Nicotine produced dose-related increases in heart rate and blood pressure and decreases in skin temperature. Nicotine also increased subjective ratings of dose strength and negative effects and decreased ratings of desire to repeat the same dose. There were dose-related trends toward decreased accuracy and increased response time on 3 of the 4 cognitive tests. These data do not support the hypothesis that nicotine enhances cognitive functioning in non-smokers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11-18 |
| Number of pages | 8 |
| Journal | Drug and Alcohol Dependence |
| Volume | 34 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1993 |
| Externally published | Yes |
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Keywords
- Cognitive performance
- Humans
- Nicotine
- Non-smokers
- Subjective effects
ASJC Scopus subject areas
- Medicine(all)
- Behavioral Neuroscience
- Toxicology
- Health(social science)
Cite this
Performance, subjective, and physiological effects of nicotine in non-smokers. / Heishman, Stephen J.; Snyder, Frederick R.; Henningfield, Jack E.
In: Drug and Alcohol Dependence, Vol. 34, No. 1, 1993, p. 11-18.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Performance, subjective, and physiological effects of nicotine in non-smokers
AU - Heishman, Stephen J.
AU - Snyder, Frederick R.
AU - Henningfield, Jack E.
PY - 1993
Y1 - 1993
N2 - Sixteen human volunteers with little or no experience using tobacco participated in one 4.5-h experimental session in which they were administered three doses of nicotine polacrilex gum (0, 2 and 4 mg) in ascending order at 90-min intervals. Physiological, subjective, and cognitive performance measures were assessed before and after each dose. Nicotine produced dose-related increases in heart rate and blood pressure and decreases in skin temperature. Nicotine also increased subjective ratings of dose strength and negative effects and decreased ratings of desire to repeat the same dose. There were dose-related trends toward decreased accuracy and increased response time on 3 of the 4 cognitive tests. These data do not support the hypothesis that nicotine enhances cognitive functioning in non-smokers.
AB - Sixteen human volunteers with little or no experience using tobacco participated in one 4.5-h experimental session in which they were administered three doses of nicotine polacrilex gum (0, 2 and 4 mg) in ascending order at 90-min intervals. Physiological, subjective, and cognitive performance measures were assessed before and after each dose. Nicotine produced dose-related increases in heart rate and blood pressure and decreases in skin temperature. Nicotine also increased subjective ratings of dose strength and negative effects and decreased ratings of desire to repeat the same dose. There were dose-related trends toward decreased accuracy and increased response time on 3 of the 4 cognitive tests. These data do not support the hypothesis that nicotine enhances cognitive functioning in non-smokers.
KW - Cognitive performance
KW - Humans
KW - Nicotine
KW - Non-smokers
KW - Subjective effects
UR - http://www.scopus.com/inward/record.url?scp=0027716720&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027716720&partnerID=8YFLogxK
U2 - 10.1016/0376-8716(93)90041-N
DO - 10.1016/0376-8716(93)90041-N
M3 - Article
C2 - 8174498
AN - SCOPUS:0027716720
VL - 34
SP - 11
EP - 18
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
SN - 0376-8716
IS - 1
ER -