Performance, subjective, and physiological effects of nicotine in non-smokers

Stephen J. Heishman; Frederick R. Snyder; Jack E. Henningfield

doi:10.1016/0376-8716(93)90041-N

Performance, subjective, and physiological effects of nicotine in non-smokers

Stephen J. Heishman, Frederick R. Snyder, Jack E. Henningfield

Research output: Contribution to journal › Article › peer-review

Abstract

Sixteen human volunteers with little or no experience using tobacco participated in one 4.5-h experimental session in which they were administered three doses of nicotine polacrilex gum (0, 2 and 4 mg) in ascending order at 90-min intervals. Physiological, subjective, and cognitive performance measures were assessed before and after each dose. Nicotine produced dose-related increases in heart rate and blood pressure and decreases in skin temperature. Nicotine also increased subjective ratings of dose strength and negative effects and decreased ratings of desire to repeat the same dose. There were dose-related trends toward decreased accuracy and increased response time on 3 of the 4 cognitive tests. These data do not support the hypothesis that nicotine enhances cognitive functioning in non-smokers.

Original language	English (US)
Pages (from-to)	11-18
Number of pages	8
Journal	Drug and Alcohol Dependence
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/0376-8716(93)90041-N
State	Published - 1993
Externally published	Yes

Keywords

Cognitive performance
Humans
Nicotine
Non-smokers
Subjective effects

ASJC Scopus subject areas

Medicine(all)
Behavioral Neuroscience
Toxicology
Health(social science)

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10.1016/0376-8716(93)90041-N

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AU - Heishman, Stephen J.

AU - Snyder, Frederick R.

AU - Henningfield, Jack E.

PY - 1993

Y1 - 1993

N2 - Sixteen human volunteers with little or no experience using tobacco participated in one 4.5-h experimental session in which they were administered three doses of nicotine polacrilex gum (0, 2 and 4 mg) in ascending order at 90-min intervals. Physiological, subjective, and cognitive performance measures were assessed before and after each dose. Nicotine produced dose-related increases in heart rate and blood pressure and decreases in skin temperature. Nicotine also increased subjective ratings of dose strength and negative effects and decreased ratings of desire to repeat the same dose. There were dose-related trends toward decreased accuracy and increased response time on 3 of the 4 cognitive tests. These data do not support the hypothesis that nicotine enhances cognitive functioning in non-smokers.

AB - Sixteen human volunteers with little or no experience using tobacco participated in one 4.5-h experimental session in which they were administered three doses of nicotine polacrilex gum (0, 2 and 4 mg) in ascending order at 90-min intervals. Physiological, subjective, and cognitive performance measures were assessed before and after each dose. Nicotine produced dose-related increases in heart rate and blood pressure and decreases in skin temperature. Nicotine also increased subjective ratings of dose strength and negative effects and decreased ratings of desire to repeat the same dose. There were dose-related trends toward decreased accuracy and increased response time on 3 of the 4 cognitive tests. These data do not support the hypothesis that nicotine enhances cognitive functioning in non-smokers.

KW - Cognitive performance

KW - Humans

KW - Nicotine

KW - Non-smokers

KW - Subjective effects

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Performance, subjective, and physiological effects of nicotine in non-smokers

Abstract

Keywords

ASJC Scopus subject areas

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