Abstract
Conclusion: There were no apparent differences in speech performance after cochlear implantation between patients with biallelic GJB2 and/or GJB6 mutations and those with deafness of unknown aetiology. These data have important implications for the selection of prognostic indicators of the outcome of cochlear implantation. Objective: To compare performance after cochlear implantation in children with mutations in GJB2 (connexin 26) and/or GJB6 (connexin 30) and children with deafness of unknown aetiology. Subjects and methods: Genetic analysis and speech performance evaluation was determined in 24 patients with (n=11) and without (n=13) biallelic GJB2 and/or GJB6 mutations who underwent cochlear implantation. Speech perception skills were measured 12 and 24 months after surgery. Each patient was classified in accordance with the speech perception category (SPC). Results: Overall, the two groups showed similar significant improvement in speech perception after implantation.
Original language | English (US) |
---|---|
Pages (from-to) | 395-398 |
Number of pages | 4 |
Journal | Acta Oto-Laryngologica |
Volume | 129 |
Issue number | 4 |
DOIs | |
State | Published - 2009 |
Externally published | Yes |
Keywords
- Cochlear implant
- Connexin 26
- Connexin 30
- Deafness
- GJB2
- GJB6
- Hearing loss
- Speech perception
ASJC Scopus subject areas
- Otorhinolaryngology