TY - JOUR
T1 - Performance of self-collected penile-meatal swabs compared to clinician-collected urethral swabs for the detection of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium by nucleic acid amplification assays
AU - Dize, Laura
AU - Barnes, Perry
AU - Barnes, Mathilda
AU - Hsieh, Yu Hsiang
AU - Marsiglia, Vincent
AU - Duncan, Della
AU - Hardick, Justin
AU - Gaydos, Charlotte A.
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Men were enrolled in a study to assess the performance and acceptability of self-collected penile meatal swabs as compared to clinician-collected urethral swabs for sexually transmitted infections (STIs). We expected penile-meatal swabs to perform favorably to urethral swabs for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV), and Mycoplasma genitalium (MG) detection by nucleic acid amplification assays (NAATs). Of 203 swab pairs tested; for CT, penile-meatal swab sensitivity was 96.8% and specificity was 98.8%. NG sensitivity and specificity were 100% and 98.9%, respectively. For TV, sensitivity was 85.0% and specificity was 96.7%. For MG sensitivity and specificity were 79.3% and 99.4%, respectively. No significant statistical differences between sample type accuracy (CT: P = 0.625; NG: P = 0.248; TV: P = 0.344; and MG: P = 0.070) existed. Most men, 90.1%, reported self-collection of penile-meatal swabs as “Very Easy” or “Easy”. Self-collected penile-meatal swabs appeared acceptable for NAAT STI detection and an acceptable collection method by men.
AB - Men were enrolled in a study to assess the performance and acceptability of self-collected penile meatal swabs as compared to clinician-collected urethral swabs for sexually transmitted infections (STIs). We expected penile-meatal swabs to perform favorably to urethral swabs for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV), and Mycoplasma genitalium (MG) detection by nucleic acid amplification assays (NAATs). Of 203 swab pairs tested; for CT, penile-meatal swab sensitivity was 96.8% and specificity was 98.8%. NG sensitivity and specificity were 100% and 98.9%, respectively. For TV, sensitivity was 85.0% and specificity was 96.7%. For MG sensitivity and specificity were 79.3% and 99.4%, respectively. No significant statistical differences between sample type accuracy (CT: P = 0.625; NG: P = 0.248; TV: P = 0.344; and MG: P = 0.070) existed. Most men, 90.1%, reported self-collection of penile-meatal swabs as “Very Easy” or “Easy”. Self-collected penile-meatal swabs appeared acceptable for NAAT STI detection and an acceptable collection method by men.
KW - Acceptability
KW - Chlamydia trachomatis
KW - Mycoplasma genitalium
KW - Neisseria gonorrhoeae
KW - Penile-meatal swabs
KW - Self-collection
KW - Trichomonas vaginalis
UR - http://www.scopus.com/inward/record.url?scp=84989968255&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84989968255&partnerID=8YFLogxK
U2 - 10.1016/j.diagmicrobio.2016.07.018
DO - 10.1016/j.diagmicrobio.2016.07.018
M3 - Article
C2 - 27497595
AN - SCOPUS:84989968255
SN - 0732-8893
VL - 86
SP - 131
EP - 135
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 2
ER -