Performance of a prototype malaria rapid diagnostic test versus thick film microscopy among HIV-positive subjects in rural Rakai, Uganda

Lisa A. Mills, Joseph Kagaayi, Joseph P. Shott, Kevin Newell, John Baptist Bwanika, Victor Ssempijja, Simon Aluma, Thomas C Quinn, Steven James Reynolds, Ronald H Gray

Research output: Contribution to journalArticle

Abstract

In this study, we report the performance of a prototype malaria rapid diagnostic test, Malaria F-test (MFT), compared with thick blood films from HIV-positive Ugandans undergoing malaria testing. In total, 21/154 samples (13.6%) were concordantly positive by both thick film and MFT and 129/154 samples (83.8%) were concordantly negative; 1 sample (0.6%) was thick film-positive but MFT-negative and 3 samples (1.9%) were thick film-negative but MFT-positive. The sensitivity of MFT was 95.5% (95% CI 77.2-99.9%) compared with thick film microscopy and the specificity was 97.7% (95% CI 93.5-99.5%). MFT was simple, rapid and effective for detection of Plasmodium falciparum among HIV-positive subjects in a rural, malaria-endemic African setting.

Original languageEnglish (US)
Pages (from-to)237-239
Number of pages3
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume104
Issue number3
DOIs
StatePublished - Mar 2010

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Uganda
Routine Diagnostic Tests
Malaria
Microscopy
HIV
Plasmodium falciparum

Keywords

  • Africa
  • Diagnosis
  • HIV/AIDS
  • Malaria
  • Rapid diagnostic test
  • Uganda

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health

Cite this

Performance of a prototype malaria rapid diagnostic test versus thick film microscopy among HIV-positive subjects in rural Rakai, Uganda. / Mills, Lisa A.; Kagaayi, Joseph; Shott, Joseph P.; Newell, Kevin; Bwanika, John Baptist; Ssempijja, Victor; Aluma, Simon; Quinn, Thomas C; Reynolds, Steven James; Gray, Ronald H.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 104, No. 3, 03.2010, p. 237-239.

Research output: Contribution to journalArticle

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