Performance monitoring local field potentials in the medial frontal cortex of primates: Anterior cingulate cortex

Erik E. Emeric, Joshua W. Brown, Melanie Leslie, Pierre Pouget, Veit Stuphorn, Jeffrey D. Schall

Research output: Contribution to journalArticle

Abstract

We describe intracranial local field potentials (LFP) recorded in the anterior cingulate cortex (ACC) of macaque monkeys performing a saccade countermanding task. The most prominent feature at ∼70% of sites was greater negative polarity after errors than after rewarded correct trials. This negative polarity was also evoked in unrewarded correct trials. The LFP evoked by the visual target was much less polarized, and the weak presaccadic modulation was insufficient to control the initiation of saccades. When saccades were cancelled, LFP modulation decreased slightly with the magnitude of response conflict that corresponds to the coactivation of gaze-shifting and -holding neurons estimated from the probability of canceling. However, response time adjustments on subsequent trials were not correlated with LFP polarity on individual trials. The results provide clear evidence that error- and feedback-related, but not conflict-related, signals are carried by the LFP in the macaque ACC. Finding performance monitoring field potentials in the ACC of macaque monkeys establishes a bridge between event-related potential and functional brain-imaging studies in humans and neurophysiology studies in non-human primates.

Original languageEnglish (US)
Pages (from-to)759-772
Number of pages14
JournalJournal of Neurophysiology
Volume99
Issue number2
DOIs
StatePublished - Feb 2008

Fingerprint

Saccades
Gyrus Cinguli
Macaca
Frontal Lobe
Primates
Haplorhini
Social Adjustment
Neurophysiology
Functional Neuroimaging
Visual Evoked Potentials
Evoked Potentials
Reaction Time
Neurons
Conflict (Psychology)

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Performance monitoring local field potentials in the medial frontal cortex of primates : Anterior cingulate cortex. / Emeric, Erik E.; Brown, Joshua W.; Leslie, Melanie; Pouget, Pierre; Stuphorn, Veit; Schall, Jeffrey D.

In: Journal of Neurophysiology, Vol. 99, No. 2, 02.2008, p. 759-772.

Research output: Contribution to journalArticle

Emeric, Erik E. ; Brown, Joshua W. ; Leslie, Melanie ; Pouget, Pierre ; Stuphorn, Veit ; Schall, Jeffrey D. / Performance monitoring local field potentials in the medial frontal cortex of primates : Anterior cingulate cortex. In: Journal of Neurophysiology. 2008 ; Vol. 99, No. 2. pp. 759-772.
@article{bc7278d7e1eb422b9ca5c3d1bba741d4,
title = "Performance monitoring local field potentials in the medial frontal cortex of primates: Anterior cingulate cortex",
abstract = "We describe intracranial local field potentials (LFP) recorded in the anterior cingulate cortex (ACC) of macaque monkeys performing a saccade countermanding task. The most prominent feature at ∼70{\%} of sites was greater negative polarity after errors than after rewarded correct trials. This negative polarity was also evoked in unrewarded correct trials. The LFP evoked by the visual target was much less polarized, and the weak presaccadic modulation was insufficient to control the initiation of saccades. When saccades were cancelled, LFP modulation decreased slightly with the magnitude of response conflict that corresponds to the coactivation of gaze-shifting and -holding neurons estimated from the probability of canceling. However, response time adjustments on subsequent trials were not correlated with LFP polarity on individual trials. The results provide clear evidence that error- and feedback-related, but not conflict-related, signals are carried by the LFP in the macaque ACC. Finding performance monitoring field potentials in the ACC of macaque monkeys establishes a bridge between event-related potential and functional brain-imaging studies in humans and neurophysiology studies in non-human primates.",
author = "Emeric, {Erik E.} and Brown, {Joshua W.} and Melanie Leslie and Pierre Pouget and Veit Stuphorn and Schall, {Jeffrey D.}",
year = "2008",
month = "2",
doi = "10.1152/jn.00896.2006",
language = "English (US)",
volume = "99",
pages = "759--772",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "2",

}

TY - JOUR

T1 - Performance monitoring local field potentials in the medial frontal cortex of primates

T2 - Anterior cingulate cortex

AU - Emeric, Erik E.

AU - Brown, Joshua W.

AU - Leslie, Melanie

AU - Pouget, Pierre

AU - Stuphorn, Veit

AU - Schall, Jeffrey D.

PY - 2008/2

Y1 - 2008/2

N2 - We describe intracranial local field potentials (LFP) recorded in the anterior cingulate cortex (ACC) of macaque monkeys performing a saccade countermanding task. The most prominent feature at ∼70% of sites was greater negative polarity after errors than after rewarded correct trials. This negative polarity was also evoked in unrewarded correct trials. The LFP evoked by the visual target was much less polarized, and the weak presaccadic modulation was insufficient to control the initiation of saccades. When saccades were cancelled, LFP modulation decreased slightly with the magnitude of response conflict that corresponds to the coactivation of gaze-shifting and -holding neurons estimated from the probability of canceling. However, response time adjustments on subsequent trials were not correlated with LFP polarity on individual trials. The results provide clear evidence that error- and feedback-related, but not conflict-related, signals are carried by the LFP in the macaque ACC. Finding performance monitoring field potentials in the ACC of macaque monkeys establishes a bridge between event-related potential and functional brain-imaging studies in humans and neurophysiology studies in non-human primates.

AB - We describe intracranial local field potentials (LFP) recorded in the anterior cingulate cortex (ACC) of macaque monkeys performing a saccade countermanding task. The most prominent feature at ∼70% of sites was greater negative polarity after errors than after rewarded correct trials. This negative polarity was also evoked in unrewarded correct trials. The LFP evoked by the visual target was much less polarized, and the weak presaccadic modulation was insufficient to control the initiation of saccades. When saccades were cancelled, LFP modulation decreased slightly with the magnitude of response conflict that corresponds to the coactivation of gaze-shifting and -holding neurons estimated from the probability of canceling. However, response time adjustments on subsequent trials were not correlated with LFP polarity on individual trials. The results provide clear evidence that error- and feedback-related, but not conflict-related, signals are carried by the LFP in the macaque ACC. Finding performance monitoring field potentials in the ACC of macaque monkeys establishes a bridge between event-related potential and functional brain-imaging studies in humans and neurophysiology studies in non-human primates.

UR - http://www.scopus.com/inward/record.url?scp=39149107737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39149107737&partnerID=8YFLogxK

U2 - 10.1152/jn.00896.2006

DO - 10.1152/jn.00896.2006

M3 - Article

C2 - 18077665

AN - SCOPUS:39149107737

VL - 99

SP - 759

EP - 772

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 2

ER -