Performance characteristics and comparison of two fecal occult blood tests in patients undergoing colonoscopy

Marcia Cruz-Correa; Kathleen Schultz; Sanjay Jagannath; Mary Harris; Sergey Kantsevoy; Marshall Bedine; Anthony N. Kalloo

doi:10.1007/s10620-006-9383-y

Performance characteristics and comparison of two fecal occult blood tests in patients undergoing colonoscopy

Marcia Cruz-Correa, Kathleen Schultz, Sanjay Jagannath, Mary Harris, Sergey Kantsevoy, Marshall Bedine, Anthony N. Kalloo

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We investigated the use of a new type of FOBT (EZ-Detect) that uses the blood's pseudo-peroxidase activity as an enzymatic catalyst, in a one-step chromogen-substrate system performed by the patient. Asymptomatic patients ≤50 years old received three Hemoccult II (HO) cards and three EZ-Detect (EZ) packages to be used in three consecutive bowel movements. Sensitivity, specificity, positive predictive value, and negative predictive value for detection of colorectal neoplasia was calculated. The study included 207 patients, with a mean age of 58.9 years. Diagnostic accuracy for detection of adenomas was similar for the EZ and HO tests (66.7% vs. 71.0%; P=0.48), while for advanced adenomas diagnostic accuracy for the EZ and HO tests was 86.0% vs. 94.2% (P=0.01), respectively. Most patients preferred the EZ test (92% vs. 8%). We conclude that the EZ test has a diagnostic profile similar to that of the HO test for identification of adenomas; however, for advanced adenomas the diagnostic accuracy was slightly better for the HO. The EZ test was preferred by most patients, which may increase colorectal cancer screening compliance.

Original language	English (US)
Pages (from-to)	1009-1013
Number of pages	5
Journal	Digestive diseases and sciences
Volume	52
Issue number	4
DOIs	https://doi.org/10.1007/s10620-006-9383-y
State	Published - Apr 2007

Keywords

Colorectal cancer
Diagnostic accuracy
Fecal occult blood testing
Screening

ASJC Scopus subject areas

Physiology
Gastroenterology

Access to Document

10.1007/s10620-006-9383-y

Cite this

@article{0e78214491664279a5c5099f785c4447,

title = "Performance characteristics and comparison of two fecal occult blood tests in patients undergoing colonoscopy",

abstract = "We investigated the use of a new type of FOBT (EZ-Detect) that uses the blood's pseudo-peroxidase activity as an enzymatic catalyst, in a one-step chromogen-substrate system performed by the patient. Asymptomatic patients ≤50 years old received three Hemoccult II (HO) cards and three EZ-Detect (EZ) packages to be used in three consecutive bowel movements. Sensitivity, specificity, positive predictive value, and negative predictive value for detection of colorectal neoplasia was calculated. The study included 207 patients, with a mean age of 58.9 years. Diagnostic accuracy for detection of adenomas was similar for the EZ and HO tests (66.7% vs. 71.0%; P=0.48), while for advanced adenomas diagnostic accuracy for the EZ and HO tests was 86.0% vs. 94.2% (P=0.01), respectively. Most patients preferred the EZ test (92% vs. 8%). We conclude that the EZ test has a diagnostic profile similar to that of the HO test for identification of adenomas; however, for advanced adenomas the diagnostic accuracy was slightly better for the HO. The EZ test was preferred by most patients, which may increase colorectal cancer screening compliance.",

keywords = "Colorectal cancer, Diagnostic accuracy, Fecal occult blood testing, Screening",

author = "Marcia Cruz-Correa and Kathleen Schultz and Sanjay Jagannath and Mary Harris and Sergey Kantsevoy and Marshall Bedine and Kalloo, {Anthony N.}",

note = "Funding Information: Acknowledgments This work was supported by Grant K07 CA092445 (to M.C.C.) and supported in part by an unrestricted grant from the Sol Hubert Trust (supplied EZ-Detect packages). None of the authors are on the Advisory Boards or Speaker Bureaus for the Sol Hubert Trust.",

year = "2007",

month = apr,

doi = "10.1007/s10620-006-9383-y",

language = "English (US)",

volume = "52",

pages = "1009--1013",

journal = "Digestive diseases and sciences",

issn = "0163-2116",

publisher = "Plenum Publishers",

number = "4",

}

TY - JOUR

T1 - Performance characteristics and comparison of two fecal occult blood tests in patients undergoing colonoscopy

AU - Cruz-Correa, Marcia

AU - Schultz, Kathleen

AU - Jagannath, Sanjay

AU - Harris, Mary

AU - Kantsevoy, Sergey

AU - Bedine, Marshall

AU - Kalloo, Anthony N.

N1 - Funding Information: Acknowledgments This work was supported by Grant K07 CA092445 (to M.C.C.) and supported in part by an unrestricted grant from the Sol Hubert Trust (supplied EZ-Detect packages). None of the authors are on the Advisory Boards or Speaker Bureaus for the Sol Hubert Trust.

PY - 2007/4

Y1 - 2007/4

N2 - We investigated the use of a new type of FOBT (EZ-Detect) that uses the blood's pseudo-peroxidase activity as an enzymatic catalyst, in a one-step chromogen-substrate system performed by the patient. Asymptomatic patients ≤50 years old received three Hemoccult II (HO) cards and three EZ-Detect (EZ) packages to be used in three consecutive bowel movements. Sensitivity, specificity, positive predictive value, and negative predictive value for detection of colorectal neoplasia was calculated. The study included 207 patients, with a mean age of 58.9 years. Diagnostic accuracy for detection of adenomas was similar for the EZ and HO tests (66.7% vs. 71.0%; P=0.48), while for advanced adenomas diagnostic accuracy for the EZ and HO tests was 86.0% vs. 94.2% (P=0.01), respectively. Most patients preferred the EZ test (92% vs. 8%). We conclude that the EZ test has a diagnostic profile similar to that of the HO test for identification of adenomas; however, for advanced adenomas the diagnostic accuracy was slightly better for the HO. The EZ test was preferred by most patients, which may increase colorectal cancer screening compliance.

AB - We investigated the use of a new type of FOBT (EZ-Detect) that uses the blood's pseudo-peroxidase activity as an enzymatic catalyst, in a one-step chromogen-substrate system performed by the patient. Asymptomatic patients ≤50 years old received three Hemoccult II (HO) cards and three EZ-Detect (EZ) packages to be used in three consecutive bowel movements. Sensitivity, specificity, positive predictive value, and negative predictive value for detection of colorectal neoplasia was calculated. The study included 207 patients, with a mean age of 58.9 years. Diagnostic accuracy for detection of adenomas was similar for the EZ and HO tests (66.7% vs. 71.0%; P=0.48), while for advanced adenomas diagnostic accuracy for the EZ and HO tests was 86.0% vs. 94.2% (P=0.01), respectively. Most patients preferred the EZ test (92% vs. 8%). We conclude that the EZ test has a diagnostic profile similar to that of the HO test for identification of adenomas; however, for advanced adenomas the diagnostic accuracy was slightly better for the HO. The EZ test was preferred by most patients, which may increase colorectal cancer screening compliance.

KW - Colorectal cancer

KW - Diagnostic accuracy

KW - Fecal occult blood testing

KW - Screening

UR - http://www.scopus.com/inward/record.url?scp=33947593115&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947593115&partnerID=8YFLogxK

U2 - 10.1007/s10620-006-9383-y

DO - 10.1007/s10620-006-9383-y

M3 - Article

C2 - 17380401

AN - SCOPUS:33947593115

SN - 0163-2116

VL - 52

SP - 1009

EP - 1013

JO - Digestive diseases and sciences

JF - Digestive diseases and sciences

IS - 4

ER -

Performance characteristics and comparison of two fecal occult blood tests in patients undergoing colonoscopy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this