Performance assessment of a NaI(Tl) gamma counter for PET applications with methods for improved quantitative accuracy and greater standardization

Martin A. Lodge, Daniel P. Holt, Paul E. Kinahan, Dean F. Wong, Richard L. Wahl

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Although NaI(Tl) gamma counters play an important role in many quantitative positron emission tomography (PET) protocols, their calibration for positron-emitting samples has not been standardized across imaging sites. In this study, we characterized the operational range of a gamma counter specifically for positron-emitting radionuclides, and we assessed the role of traceable 68Ge/68Ga sources for standardizing system calibration. Methods: A NaI(Tl) gamma counter was characterized with respect to count rate performance, adequacy of detector shielding, system stability, and sample volume effects using positron-emitting radionuclides (409- to 613-keV energy window). System efficiency was measured using 18F and compared with corresponding data obtained using a long-lived 68Ge/68Ga source that was implicitly traceable to a national standard. Results: One percent count loss was measured at 450 × 103 counts per minute. Penetration of the detector shielding by 511-keV photons gave rise to a negligible background count rate. System stability tests showed a coefficient of variation of 0.13% over 100 days. For a sample volume of 4 mL, the efficiencies relative to those at 0.1 mL were 0.96, 0.94, 0.91, 0.78, and 0.72 for 11C, 18F, 125I, 99mTc, and 51Cr, respectively. The efficiency of a traceable 68Ge/68Ga source was 30.1% ± 0.07% and was found to be in close agreement with the efficiency for 18F after consideration of the different positron fractions. Conclusions: Long-lived 68Ge/68Ga reference sources, implicitly traceable to a national metrology institute, can aid standardization of gamma counter calibration for 18F. A characteristic feature of positron emitters meant that accurate calibration could be maintained over a wide range of sample volumes by using a narrow energy window centered on the 511-keV peak.

Original languageEnglish (US)
Article number11
Pages (from-to)1-13
Number of pages13
JournalEJNMMI Physics
Volume2
Issue number1
DOIs
StatePublished - Dec 1 2015

Keywords

  • Calibration
  • Efficiency
  • Gamma counter
  • Positron emission tomography
  • Sample volume
  • Standardization
  • Well counter

ASJC Scopus subject areas

  • Radiation
  • Biomedical Engineering
  • Instrumentation
  • Radiology Nuclear Medicine and imaging

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