Perfluoroalkyl chemicals, menstrual cycle length, and fecundity

Kirsten J. Lum, Rajeshwari Sundaram, Dana B. Barr, Thomas Louis, Germaine M. Buck Louis

Research output: Contribution to journalArticle

Abstract

Background: Perfluoroalkyl substances have been associated with changes in menstrual cycle characteristics and fecundity, when modeled separately. However, these outcomes are biologically related, and we evaluate their joint association with exposure to perfluoroalkyl substances. Methods: We recruited 501 couples from Michigan and Texas in 2005-2009 upon their discontinuing contraception and followed them until pregnancy or 12 months of trying. Female partners provided a serum sample on enrollment and completed daily journals on menstruation, intercourse, and pregnancy test results. We measured seven perfluoroalkyl substances in serum using liquid chromatography-tandem mass spectrometry. We assessed the association between perfluoroalkyl substances and menstrual cycle length using accelerated failure time models and between perfluoroalkyl substances and fecundity using a Bayesian joint modeling approach to incorporate cycle length. Results: Menstrual cycles were 3% longer comparing women in the second versus first tertile of perfluorodecanoate (PFDeA; acceleration factor [AF] = 1.03, 95% credible interval [CrI] = [1.00, 1.05]), but 2% shorter for women in the highest versus lowest tertile of perfluorooctanoic acid (PFOA; AF = 0.98, 95% CrI = [0.96, 1.00]). When accounting for cycle length, relevant covariates, and remaining perfluoroalkyl substances, the probability of pregnancy was lower for women in second versus first tertile of perfluorononanoate (PFNA; odds ratio [OR] = 0.6, 95% CrI = [0.4, 1.0]) although not when comparing the highest versus lowest (OR = 0.7, 95% CrI = [0.3, 1.1]) tertile. Conclusions: In this prospective cohort study, we observed associations between two perfluoroalkyl substances and menstrual cycle length changes, and between select perfluoroalkyl substances and diminished fecundity at some (but not all) concentrations. See video abstract at, http://links.lww.com/EDE/B136.

Original languageEnglish (US)
Pages (from-to)90-98
Number of pages9
JournalEpidemiology
Volume28
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

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Menstrual Cycle
Fertility
perfluorooctanoic acid
Odds Ratio
Pregnancy Tests
Pregnancy
Menstruation
Tandem Mass Spectrometry
Serum
Contraception
Liquid Chromatography
Cohort Studies
Joints
Prospective Studies

ASJC Scopus subject areas

  • Epidemiology

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Perfluoroalkyl chemicals, menstrual cycle length, and fecundity. / Lum, Kirsten J.; Sundaram, Rajeshwari; Barr, Dana B.; Louis, Thomas; Buck Louis, Germaine M.

In: Epidemiology, Vol. 28, No. 1, 01.01.2017, p. 90-98.

Research output: Contribution to journalArticle

Lum, KJ, Sundaram, R, Barr, DB, Louis, T & Buck Louis, GM 2017, 'Perfluoroalkyl chemicals, menstrual cycle length, and fecundity', Epidemiology, vol. 28, no. 1, pp. 90-98. https://doi.org/10.1097/EDE.0000000000000552
Lum, Kirsten J. ; Sundaram, Rajeshwari ; Barr, Dana B. ; Louis, Thomas ; Buck Louis, Germaine M. / Perfluoroalkyl chemicals, menstrual cycle length, and fecundity. In: Epidemiology. 2017 ; Vol. 28, No. 1. pp. 90-98.
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