Percutaneous retrogasserian glycerol rhizotomy. Predictors of success and failure in treatment of trigeminal neuralgia

R. B. North, D. H. Kidd, S. Piantadosi, Benjamin Solomon

Research output: Contribution to journalArticle

Abstract

Eighty-five medically intractable trigeminal neuralgia patients treated by percutaneous retrogasserian glycerol rhizotomy (PRGR) were followed for 6 to 54 months. The median time to recurrence of symptoms refractory to medical therapy and requiring further intervention was 3 years (by Kaplan-Meier survival analysis). The median time to recurrence of symptoms requiring some form of medical treatment was 2 years. Following repeat PRGR for recurrent symptoms, the median time to recurrence was 1 year. Univariate log rank statistics and multivariate Cox proportional hazards modeling revealed significant associations between favorable outcome and female sex, absence of atypical features or associated cluster headache symptoms, success of prior carbamazepine therapy, duration of symptoms, and cerebrospinal fluid return during the procedure. A scoring system using prognostic factors has been developed based upon these findings. Assessment of published studies of PRGR and of other treatments for trigeminal neuralgia is made difficult by the variety of outcome measures employed and variable follow-up intervals. The present study attempts to address these issues by definition of endpoints, statistical analysis of the data, and identification of important prognostic factors in a manner useful to the clinician.

Original languageEnglish (US)
Pages (from-to)851-856
Number of pages6
JournalJournal of Neurosurgery
Volume72
Issue number6
StatePublished - 1990

Fingerprint

Rhizotomy
Trigeminal Neuralgia
Treatment Failure
Glycerol
Recurrence
Cluster Headache
Statistical Data Interpretation
Carbamazepine
Kaplan-Meier Estimate
Therapeutics
Survival Analysis
Cerebrospinal Fluid
Outcome Assessment (Health Care)

Keywords

  • glycerol
  • percutaneous procedure
  • rhizotomy
  • Trigeminal neuralgia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Percutaneous retrogasserian glycerol rhizotomy. Predictors of success and failure in treatment of trigeminal neuralgia. / North, R. B.; Kidd, D. H.; Piantadosi, S.; Solomon, Benjamin.

In: Journal of Neurosurgery, Vol. 72, No. 6, 1990, p. 851-856.

Research output: Contribution to journalArticle

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