Percutaneous Image-guided Radiofrequency Thermal Ablation for Large Symptomatic Uterine Leiomyomata after Uterine Artery Embolization: A Feasibility and Safety Study

Hyun S. Kim, Jason Tsai, Michael A. Jacobs, Ihab R. Kamel

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the feasibility and safety of percutaneous image-guided radiofrequency ablation (RFA) performed with moderate sedation for large symptomatic uterine leiomyomata. Materials and methods: Women with large (>5 cm in diameter) symptomatic subserosal and/or intramural uterine leiomyoma were recruited for a prospective study. Patients underwent percutaneous RFA following UAE. RFA using 5 cm treatment diameter expandable needle electrodes connected to a 460 kHz monopolar RF generator, which was performed with a target temperature and power set at 85°C and 150 watts respectively, with a target temperature ablation time of 10 minutes. Patients were assessed for complications in perioperative and post-procedure periods at 24 hours and 1 month, and for symptom improvements at 6 months. Results: Thirty-five patients (mean 43.8 years ± 6.2) were recruited. RFA targeting ablation size and temperature was achieved in 97% of the patients (34/35). There were no immediate percutaneous RFA-related complications. There was a self-limiting delayed drainage via the transabdominal RFA access track in one patient (2.9%), a urinary tract infection in one patient (2.9%) and post-embolization/post-ablation symptoms in three patients (8.6%). The mean transformed symptom severity score (SSS) as a part of the uterine fibroid symptom and quality of life (UFS-QOL) assessment shows that the improvements at 1 month were 24.3 points (P < 0.001) and at 6 months were 40.4 points (P < 0.001). Mean volume reduction of leiomyomata was 286.8 cm3 or 56.5% (P = 0.0015). Conclusions: Percutaneous image-guided RFA as adjunctive to UAE under moderate sedation is feasible, and appears safe without significant morbidity in the treatment of large uterine leiomyomata.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalJournal of Vascular and Interventional Radiology
Volume18
Issue number1
DOIs
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Percutaneous Image-guided Radiofrequency Thermal Ablation for Large Symptomatic Uterine Leiomyomata after Uterine Artery Embolization: A Feasibility and Safety Study'. Together they form a unique fingerprint.

  • Cite this