Percutaneous image-guided radiofrequency ablation of painful metastases involving bone

A multicenter study

Matthew P. Goetz, Matthew R. Callstrom, J. William Charboneau, Michael A. Farrell, Timothy P. Mans, Timothy J. Welch, Gilbert Y. Wong, Jeff A. Sloan, Paul J. Novotny, Ivy A. Petersen, Robert A. Beres, Daniele Regge, Rodolfo Capanna, Mark B. Saker, Dietrich H W Grönemeyer, Athour Gevargez, Kamran Ahrar, Michael A. Choti, Thierry J. Debaere, Joseph Rubin

Research output: Contribution to journalArticle

Abstract

Purpose: Few options are available for pain relief in patients with bone metastases who fail standard treatments. We sought to determine the benefit of radiofrequency ablation (RFA) in providing pain relief for patients with refractory pain secondary to metastases involving bone. Patients and Methods: Thirty-one US and 12 European patients with painful osteolytic metastases involving bone were treated with image-guided RFA using a multitip needle. Treated patients had ≥ 4/10 pain and had either failed or were poor candidates for standard treatments such as radiation or opioid analgesics. Using the Brief Pain Inventory-Short Form, worst pain intensity was the primary end point, with a 2-unit drop considered clinically significant. Results: Forty-three patients were treated (median follow-up, 16 weeks). Before RFA, the mean score for worst pain was 7.9 (range, 4/10 to 10/10). Four, 12, and 24 weeks following treatment, worst pain decreased to 4.5 (P <.0001), 3.0 (P <.0001), and 1.4 (P = .0005), respectively. Ninety-five percent (41 of 43 patients) experienced a decrease in pain that was considered clinically significant. Opioid usage significantly decreased at weeks 8 and 12. Adverse events were seen in 3 patients and included (1) a second-degree skin burn at the grounding pad site, (2) transient bowel and bladder incontinence following treatment of a metastasis involving the sacrum, and (3) a fracture of the acetabulum following RFA of an acetabular lesion. Conclusion: RFA of painful osteolytic metastases provides significant pain relief for cancer patients who have failed standard treatments.

Original languageEnglish (US)
Pages (from-to)300-306
Number of pages7
JournalJournal of Clinical Oncology
Volume22
Issue number2
DOIs
StatePublished - 2004
Externally publishedYes

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Multicenter Studies
Neoplasm Metastasis
Bone and Bones
Pain
Opioid Analgesics
Therapeutics
Sacrum
Intractable Pain
Acetabulum
Needles
Urinary Bladder
Radiation
Equipment and Supplies
Skin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Goetz, M. P., Callstrom, M. R., Charboneau, J. W., Farrell, M. A., Mans, T. P., Welch, T. J., ... Rubin, J. (2004). Percutaneous image-guided radiofrequency ablation of painful metastases involving bone: A multicenter study. Journal of Clinical Oncology, 22(2), 300-306. https://doi.org/10.1200/JCO.2004.03.097

Percutaneous image-guided radiofrequency ablation of painful metastases involving bone : A multicenter study. / Goetz, Matthew P.; Callstrom, Matthew R.; Charboneau, J. William; Farrell, Michael A.; Mans, Timothy P.; Welch, Timothy J.; Wong, Gilbert Y.; Sloan, Jeff A.; Novotny, Paul J.; Petersen, Ivy A.; Beres, Robert A.; Regge, Daniele; Capanna, Rodolfo; Saker, Mark B.; Grönemeyer, Dietrich H W; Gevargez, Athour; Ahrar, Kamran; Choti, Michael A.; Debaere, Thierry J.; Rubin, Joseph.

In: Journal of Clinical Oncology, Vol. 22, No. 2, 2004, p. 300-306.

Research output: Contribution to journalArticle

Goetz, MP, Callstrom, MR, Charboneau, JW, Farrell, MA, Mans, TP, Welch, TJ, Wong, GY, Sloan, JA, Novotny, PJ, Petersen, IA, Beres, RA, Regge, D, Capanna, R, Saker, MB, Grönemeyer, DHW, Gevargez, A, Ahrar, K, Choti, MA, Debaere, TJ & Rubin, J 2004, 'Percutaneous image-guided radiofrequency ablation of painful metastases involving bone: A multicenter study', Journal of Clinical Oncology, vol. 22, no. 2, pp. 300-306. https://doi.org/10.1200/JCO.2004.03.097
Goetz, Matthew P. ; Callstrom, Matthew R. ; Charboneau, J. William ; Farrell, Michael A. ; Mans, Timothy P. ; Welch, Timothy J. ; Wong, Gilbert Y. ; Sloan, Jeff A. ; Novotny, Paul J. ; Petersen, Ivy A. ; Beres, Robert A. ; Regge, Daniele ; Capanna, Rodolfo ; Saker, Mark B. ; Grönemeyer, Dietrich H W ; Gevargez, Athour ; Ahrar, Kamran ; Choti, Michael A. ; Debaere, Thierry J. ; Rubin, Joseph. / Percutaneous image-guided radiofrequency ablation of painful metastases involving bone : A multicenter study. In: Journal of Clinical Oncology. 2004 ; Vol. 22, No. 2. pp. 300-306.
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abstract = "Purpose: Few options are available for pain relief in patients with bone metastases who fail standard treatments. We sought to determine the benefit of radiofrequency ablation (RFA) in providing pain relief for patients with refractory pain secondary to metastases involving bone. Patients and Methods: Thirty-one US and 12 European patients with painful osteolytic metastases involving bone were treated with image-guided RFA using a multitip needle. Treated patients had ≥ 4/10 pain and had either failed or were poor candidates for standard treatments such as radiation or opioid analgesics. Using the Brief Pain Inventory-Short Form, worst pain intensity was the primary end point, with a 2-unit drop considered clinically significant. Results: Forty-three patients were treated (median follow-up, 16 weeks). Before RFA, the mean score for worst pain was 7.9 (range, 4/10 to 10/10). Four, 12, and 24 weeks following treatment, worst pain decreased to 4.5 (P <.0001), 3.0 (P <.0001), and 1.4 (P = .0005), respectively. Ninety-five percent (41 of 43 patients) experienced a decrease in pain that was considered clinically significant. Opioid usage significantly decreased at weeks 8 and 12. Adverse events were seen in 3 patients and included (1) a second-degree skin burn at the grounding pad site, (2) transient bowel and bladder incontinence following treatment of a metastasis involving the sacrum, and (3) a fracture of the acetabulum following RFA of an acetabular lesion. Conclusion: RFA of painful osteolytic metastases provides significant pain relief for cancer patients who have failed standard treatments.",
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T2 - A multicenter study

AU - Goetz, Matthew P.

AU - Callstrom, Matthew R.

AU - Charboneau, J. William

AU - Farrell, Michael A.

AU - Mans, Timothy P.

AU - Welch, Timothy J.

AU - Wong, Gilbert Y.

AU - Sloan, Jeff A.

AU - Novotny, Paul J.

AU - Petersen, Ivy A.

AU - Beres, Robert A.

AU - Regge, Daniele

AU - Capanna, Rodolfo

AU - Saker, Mark B.

AU - Grönemeyer, Dietrich H W

AU - Gevargez, Athour

AU - Ahrar, Kamran

AU - Choti, Michael A.

AU - Debaere, Thierry J.

AU - Rubin, Joseph

PY - 2004

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N2 - Purpose: Few options are available for pain relief in patients with bone metastases who fail standard treatments. We sought to determine the benefit of radiofrequency ablation (RFA) in providing pain relief for patients with refractory pain secondary to metastases involving bone. Patients and Methods: Thirty-one US and 12 European patients with painful osteolytic metastases involving bone were treated with image-guided RFA using a multitip needle. Treated patients had ≥ 4/10 pain and had either failed or were poor candidates for standard treatments such as radiation or opioid analgesics. Using the Brief Pain Inventory-Short Form, worst pain intensity was the primary end point, with a 2-unit drop considered clinically significant. Results: Forty-three patients were treated (median follow-up, 16 weeks). Before RFA, the mean score for worst pain was 7.9 (range, 4/10 to 10/10). Four, 12, and 24 weeks following treatment, worst pain decreased to 4.5 (P <.0001), 3.0 (P <.0001), and 1.4 (P = .0005), respectively. Ninety-five percent (41 of 43 patients) experienced a decrease in pain that was considered clinically significant. Opioid usage significantly decreased at weeks 8 and 12. Adverse events were seen in 3 patients and included (1) a second-degree skin burn at the grounding pad site, (2) transient bowel and bladder incontinence following treatment of a metastasis involving the sacrum, and (3) a fracture of the acetabulum following RFA of an acetabular lesion. Conclusion: RFA of painful osteolytic metastases provides significant pain relief for cancer patients who have failed standard treatments.

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