Percutaneous Endoscopic Gastrostomy Tubes May Be Associated With Preservation of Lung Function in Patients With Cystic Fibrosis

Racha T. Khalaf, Deanna Green, Ernest Amankwah, Jacquelin Peck, Vanessa Carr, Neil Goldenberg, Michael Wilsey

Research output: Contribution to journalArticle

Abstract

Background: Improving nutrition status of patients with cystic fibrosis (CF) has a positive effect on pulmonary function. Methods: We conducted a retrospective case-control study evaluating the effect of percutaneous endoscopic gastrostomy (PEG) placement on body mass index (BMI) and forced expiratory volume in 1 second percent predicted (FEV1) between matched subjects with CF who received PEG (n = 20) and controls who did not (n = 40). Results: We observed that after adjusting for mutation class and baseline BMI, BMI percentile increased per month for those with PEG (0.51, 95% confidence interval (CI) = −0.05–1.08, P =.08), but decreased for those without PEG (−0.03, 95% CI = −0.33–0.28, P =.86); however, the difference (0.54; 95% CI = −0.10–1.18, P =.10) was not statistically significant. FEV1 change with time showed a decrease for patients with PEG (−0.04; 95% CI = −0.30–0.22, P =.74) and those without PEG (−.22; 95% CI = −0.45–0.01, P =.06). Although the decrease for those without PEG was higher than those with PEG, the difference between the groups was not statistically significant (0.18; 95% CI = −0.17–0.52, P =.32). Conclusion: Lung function trajectory showed a trend towards preservation among patients with CF who receive PEG despite lack of significant difference in BMI. There may be a favorable effect of PEG on lung function independent of changes in BMI.

Original languageEnglish (US)
JournalNutrition in Clinical Practice
DOIs
StateAccepted/In press - Jan 1 2018

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Gastrostomy
Cystic Fibrosis
Lung
Confidence Intervals
Body Mass Index
Forced Expiratory Volume
Nutritional Status
Case-Control Studies
Mutation

Keywords

  • cystic fibrosis
  • enteral nutrition
  • forced expiratory volume
  • gastrostomy
  • respiratory function tests

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

@article{46432a309e864d428f8eba9e6cec757b,
title = "Percutaneous Endoscopic Gastrostomy Tubes May Be Associated With Preservation of Lung Function in Patients With Cystic Fibrosis",
abstract = "Background: Improving nutrition status of patients with cystic fibrosis (CF) has a positive effect on pulmonary function. Methods: We conducted a retrospective case-control study evaluating the effect of percutaneous endoscopic gastrostomy (PEG) placement on body mass index (BMI) and forced expiratory volume in 1 second percent predicted (FEV1) between matched subjects with CF who received PEG (n = 20) and controls who did not (n = 40). Results: We observed that after adjusting for mutation class and baseline BMI, BMI percentile increased per month for those with PEG (0.51, 95{\%} confidence interval (CI) = −0.05–1.08, P =.08), but decreased for those without PEG (−0.03, 95{\%} CI = −0.33–0.28, P =.86); however, the difference (0.54; 95{\%} CI = −0.10–1.18, P =.10) was not statistically significant. FEV1 change with time showed a decrease for patients with PEG (−0.04; 95{\%} CI = −0.30–0.22, P =.74) and those without PEG (−.22; 95{\%} CI = −0.45–0.01, P =.06). Although the decrease for those without PEG was higher than those with PEG, the difference between the groups was not statistically significant (0.18; 95{\%} CI = −0.17–0.52, P =.32). Conclusion: Lung function trajectory showed a trend towards preservation among patients with CF who receive PEG despite lack of significant difference in BMI. There may be a favorable effect of PEG on lung function independent of changes in BMI.",
keywords = "cystic fibrosis, enteral nutrition, forced expiratory volume, gastrostomy, respiratory function tests",
author = "Khalaf, {Racha T.} and Deanna Green and Ernest Amankwah and Jacquelin Peck and Vanessa Carr and Neil Goldenberg and Michael Wilsey",
year = "2018",
month = "1",
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doi = "10.1002/ncp.10219",
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T1 - Percutaneous Endoscopic Gastrostomy Tubes May Be Associated With Preservation of Lung Function in Patients With Cystic Fibrosis

AU - Khalaf, Racha T.

AU - Green, Deanna

AU - Amankwah, Ernest

AU - Peck, Jacquelin

AU - Carr, Vanessa

AU - Goldenberg, Neil

AU - Wilsey, Michael

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Improving nutrition status of patients with cystic fibrosis (CF) has a positive effect on pulmonary function. Methods: We conducted a retrospective case-control study evaluating the effect of percutaneous endoscopic gastrostomy (PEG) placement on body mass index (BMI) and forced expiratory volume in 1 second percent predicted (FEV1) between matched subjects with CF who received PEG (n = 20) and controls who did not (n = 40). Results: We observed that after adjusting for mutation class and baseline BMI, BMI percentile increased per month for those with PEG (0.51, 95% confidence interval (CI) = −0.05–1.08, P =.08), but decreased for those without PEG (−0.03, 95% CI = −0.33–0.28, P =.86); however, the difference (0.54; 95% CI = −0.10–1.18, P =.10) was not statistically significant. FEV1 change with time showed a decrease for patients with PEG (−0.04; 95% CI = −0.30–0.22, P =.74) and those without PEG (−.22; 95% CI = −0.45–0.01, P =.06). Although the decrease for those without PEG was higher than those with PEG, the difference between the groups was not statistically significant (0.18; 95% CI = −0.17–0.52, P =.32). Conclusion: Lung function trajectory showed a trend towards preservation among patients with CF who receive PEG despite lack of significant difference in BMI. There may be a favorable effect of PEG on lung function independent of changes in BMI.

AB - Background: Improving nutrition status of patients with cystic fibrosis (CF) has a positive effect on pulmonary function. Methods: We conducted a retrospective case-control study evaluating the effect of percutaneous endoscopic gastrostomy (PEG) placement on body mass index (BMI) and forced expiratory volume in 1 second percent predicted (FEV1) between matched subjects with CF who received PEG (n = 20) and controls who did not (n = 40). Results: We observed that after adjusting for mutation class and baseline BMI, BMI percentile increased per month for those with PEG (0.51, 95% confidence interval (CI) = −0.05–1.08, P =.08), but decreased for those without PEG (−0.03, 95% CI = −0.33–0.28, P =.86); however, the difference (0.54; 95% CI = −0.10–1.18, P =.10) was not statistically significant. FEV1 change with time showed a decrease for patients with PEG (−0.04; 95% CI = −0.30–0.22, P =.74) and those without PEG (−.22; 95% CI = −0.45–0.01, P =.06). Although the decrease for those without PEG was higher than those with PEG, the difference between the groups was not statistically significant (0.18; 95% CI = −0.17–0.52, P =.32). Conclusion: Lung function trajectory showed a trend towards preservation among patients with CF who receive PEG despite lack of significant difference in BMI. There may be a favorable effect of PEG on lung function independent of changes in BMI.

KW - cystic fibrosis

KW - enteral nutrition

KW - forced expiratory volume

KW - gastrostomy

KW - respiratory function tests

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