Percutaneous access: Acute effects on renal function and structure in a porcine model

Rajash K. Handa, Lynn R. Willis, Andrew P. Evan, Bret A. Connors, Jun Ying, William Fat-Anthony, Kelli R. Wind, Cynthia D. Johnson, Philip M. Blomgren, Mark C. Estrada, Ryan F. Paterson, Ramsay L. Kuo, Samuel C. Kim, Brian R. Matlaga, Nicole L. Miller, Stephanie L. Watkins, Shelly E. Handa, James E. Lingeman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


Percutaneous nephrolithotomy (PCNL) involves gaining access into the urinary collecting system to remove kidney stones. Animal studies demonstrated that a reduction in renal filtration and perfusion in both kidneys, and a decline in tubular organic anion transport in the treated kidney characterizes the acute (hours) functional response to unilateral percutaneous access. The acute morphologic and histological changes in the treated kidney were consistent with blunt trauma and ischemia. Only tubular organic anion transport remained depressed during the late (3-day) response to the access procedure. Human studies revealed an acute decline in glomerular function and bilateral renal vasoconstriction following unilateral PCNL. Therefore, percutaneous access is not a benign procedure, but is associated with acute functional and structural derangements.

Original languageEnglish (US)
Title of host publicationRENAL STONE DISEASE
Subtitle of host publication1st Annual International Urolithiasis Research Symposium
PublisherAmerican Institute of Physics Inc.
Number of pages8
ISBN (Print)0735404062, 9780735404069
StatePublished - 2007
Externally publishedYes
Event1st Annual International Urolithiasis Research Symposium - Indianapolis, IN, United States
Duration: Nov 2 2006Nov 3 2006

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


Other1st Annual International Urolithiasis Research Symposium
Country/TerritoryUnited States
CityIndianapolis, IN


  • Kidney function
  • Percutaneous access
  • Percutaneous nephrolithotomy
  • Tract dilation

ASJC Scopus subject areas

  • Physics and Astronomy(all)


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