Percutaneous access: Acute effects on renal function and structure in a porcine model

Rajash K. Handa; Lynn R. Willis; Andrew P. Evan; Bret A. Connors; Jun Ying; William Fat-Anthony; Kelli R. Wind; Cynthia D. Johnson; Philip M. Blomgren; Mark C. Estrada; Ryan F. Paterson; Ramsay L. Kuo; Samuel C. Kim; Brian R. Matlaga; Nicole L. Miller; Stephanie L. Watkins; Shelly E. Handa; James E. Lingeman

doi:10.1063/1.2723582

Percutaneous access: Acute effects on renal function and structure in a porcine model

Rajash K. Handa, Lynn R. Willis, Andrew P. Evan, Bret A. Connors, Jun Ying, William Fat-Anthony, Kelli R. Wind, Cynthia D. Johnson, Philip M. Blomgren, Mark C. Estrada, Ryan F. Paterson, Ramsay L. Kuo, Samuel C. Kim, Brian R. Matlaga, Nicole L. Miller, Stephanie L. Watkins, Shelly E. Handa, James E. Lingeman

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Percutaneous nephrolithotomy (PCNL) involves gaining access into the urinary collecting system to remove kidney stones. Animal studies demonstrated that a reduction in renal filtration and perfusion in both kidneys, and a decline in tubular organic anion transport in the treated kidney characterizes the acute (hours) functional response to unilateral percutaneous access. The acute morphologic and histological changes in the treated kidney were consistent with blunt trauma and ischemia. Only tubular organic anion transport remained depressed during the late (3-day) response to the access procedure. Human studies revealed an acute decline in glomerular function and bilateral renal vasoconstriction following unilateral PCNL. Therefore, percutaneous access is not a benign procedure, but is associated with acute functional and structural derangements.

Original language	English (US)
Title of host publication	RENAL STONE DISEASE
Subtitle of host publication	1st Annual International Urolithiasis Research Symposium
Publisher	American Institute of Physics Inc.
Pages	233-240
Number of pages	8
ISBN (Print)	0735404062, 9780735404069
DOIs	https://doi.org/10.1063/1.2723582
State	Published - 2007
Event	1st Annual International Urolithiasis Research Symposium - Indianapolis, IN, United States Duration: Nov 2 2006 → Nov 3 2006

Publication series

Name	AIP Conference Proceedings
Volume	900
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Other

Other	1st Annual International Urolithiasis Research Symposium
Country	United States
City	Indianapolis, IN
Period	11/2/06 → 11/3/06

Keywords

Kidney function
Percutaneous access
Percutaneous nephrolithotomy
Tract dilation

ASJC Scopus subject areas

Physics and Astronomy(all)

Access to Document

10.1063/1.2723582

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Cite this

Handa, R. K., Willis, L. R., Evan, A. P., Connors, B. A., Ying, J., Fat-Anthony, W., Wind, K. R., Johnson, C. D., Blomgren, P. M., Estrada, M. C., Paterson, R. F., Kuo, R. L., Kim, S. C., Matlaga, B. R., Miller, N. L., Watkins, S. L., Handa, S. E., & Lingeman, J. E. (2007). Percutaneous access: Acute effects on renal function and structure in a porcine model. In RENAL STONE DISEASE: 1st Annual International Urolithiasis Research Symposium (pp. 233-240). (AIP Conference Proceedings; Vol. 900). American Institute of Physics Inc.. https://doi.org/10.1063/1.2723582

Percutaneous access : Acute effects on renal function and structure in a porcine model. / Handa, Rajash K.; Willis, Lynn R.; Evan, Andrew P.; Connors, Bret A.; Ying, Jun; Fat-Anthony, William; Wind, Kelli R.; Johnson, Cynthia D.; Blomgren, Philip M.; Estrada, Mark C.; Paterson, Ryan F.; Kuo, Ramsay L.; Kim, Samuel C.; Matlaga, Brian R.; Miller, Nicole L.; Watkins, Stephanie L.; Handa, Shelly E.; Lingeman, James E.

RENAL STONE DISEASE: 1st Annual International Urolithiasis Research Symposium. American Institute of Physics Inc., 2007. p. 233-240 (AIP Conference Proceedings; Vol. 900).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Handa, RK, Willis, LR, Evan, AP, Connors, BA, Ying, J, Fat-Anthony, W, Wind, KR, Johnson, CD, Blomgren, PM, Estrada, MC, Paterson, RF, Kuo, RL, Kim, SC, Matlaga, BR, Miller, NL, Watkins, SL, Handa, SE & Lingeman, JE 2007, Percutaneous access: Acute effects on renal function and structure in a porcine model. in RENAL STONE DISEASE: 1st Annual International Urolithiasis Research Symposium. AIP Conference Proceedings, vol. 900, American Institute of Physics Inc., pp. 233-240, 1st Annual International Urolithiasis Research Symposium, Indianapolis, IN, United States, 11/2/06. https://doi.org/10.1063/1.2723582

Handa, Rajash K. ; Willis, Lynn R. ; Evan, Andrew P. ; Connors, Bret A. ; Ying, Jun ; Fat-Anthony, William ; Wind, Kelli R. ; Johnson, Cynthia D. ; Blomgren, Philip M. ; Estrada, Mark C. ; Paterson, Ryan F. ; Kuo, Ramsay L. ; Kim, Samuel C. ; Matlaga, Brian R. ; Miller, Nicole L. ; Watkins, Stephanie L. ; Handa, Shelly E. ; Lingeman, James E. / Percutaneous access : Acute effects on renal function and structure in a porcine model. RENAL STONE DISEASE: 1st Annual International Urolithiasis Research Symposium. American Institute of Physics Inc., 2007. pp. 233-240 (AIP Conference Proceedings).

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