Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese adolescents

Xiumei Hong, Lester M. Arguelles, Xin Liu, Hui Ju Tsai, Yi Hsiang Hsu, Binyan Wang, Shanchun Zhang, Zhiping Li, Gengfu Tang, Xue Liu, Jianhua Yang, Xiping Xu, Craig Langman, Xiaobin Wang

Research output: Contribution to journalArticle

Abstract

This study was an attempt to examine the phenotypic, genetic, and environmental correlations between percent fat mass (PFM) and bone parameters, especially hip geometry, among 786 males and 618 females aged 13 to 21 years from a Chinese twin cohort. PFM, bone area (BA), bone mineral content (BMC), cross-sectional area (CSA), and section modulus (SM) were obtained by dual-energy X-ray absorptiometry. Multiple linear regression models were used to assess the PFM-bone relationships. A structural equation model for twin design was used to estimate genetic/environmental influences on individual phenotype and phenotypic correlations. After controlling for body weight and other pertinent covariates, we observed inverse associations between PFM and bone parameters: Compared with the lowest age- and gender-specific tertile of PFM, males in the highest tertile of PFM had lower measures of whole-body-less-head BA (WB-BA), lumbar spine BA (L2-L4-BA), total-hip BA (TH-BA), total-hip BMC, CSA, and SM (p4-BA. These associations did not vary significantly by Tanner stages. In both genders, the estimated heritabilities were 80% to 86% for BMC, 67% to 80% for BA, 74% to 77% for CSA, and 64% for SM. Both shared genetics and environmental factors contributed to the inverse PFM-bone correlations. We conclude that in this sample of relatively lean Chinese adolescents, at a given body weight, PFM is inversely associated with BA, BMC, and hip geometry in both genders, and such associations are attributed to both shared genetic and environmental factors.

Original languageEnglish (US)
Pages (from-to)1544-1554
Number of pages11
JournalJournal of Bone and Mineral Research
Volume25
Issue number7
DOIs
StatePublished - Jul 2010
Externally publishedYes

Fingerprint

Pelvic Bones
Fats
Bone and Bones
Bone Density
Hip
Linear Models
Body Weight
Body Weights and Measures
Structural Models
Photon Absorptiometry
Spine

Keywords

  • Adolescence
  • Bone mineral content
  • Coheritability
  • Hip geometry
  • Percent fat mass

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese adolescents. / Hong, Xiumei; Arguelles, Lester M.; Liu, Xin; Tsai, Hui Ju; Hsu, Yi Hsiang; Wang, Binyan; Zhang, Shanchun; Li, Zhiping; Tang, Gengfu; Liu, Xue; Yang, Jianhua; Xu, Xiping; Langman, Craig; Wang, Xiaobin.

In: Journal of Bone and Mineral Research, Vol. 25, No. 7, 07.2010, p. 1544-1554.

Research output: Contribution to journalArticle

Hong, X, Arguelles, LM, Liu, X, Tsai, HJ, Hsu, YH, Wang, B, Zhang, S, Li, Z, Tang, G, Liu, X, Yang, J, Xu, X, Langman, C & Wang, X 2010, 'Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese adolescents', Journal of Bone and Mineral Research, vol. 25, no. 7, pp. 1544-1554. https://doi.org/10.1002/jbmr.40
Hong, Xiumei ; Arguelles, Lester M. ; Liu, Xin ; Tsai, Hui Ju ; Hsu, Yi Hsiang ; Wang, Binyan ; Zhang, Shanchun ; Li, Zhiping ; Tang, Gengfu ; Liu, Xue ; Yang, Jianhua ; Xu, Xiping ; Langman, Craig ; Wang, Xiaobin. / Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese adolescents. In: Journal of Bone and Mineral Research. 2010 ; Vol. 25, No. 7. pp. 1544-1554.
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AU - Hong, Xiumei

AU - Arguelles, Lester M.

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AU - Wang, Binyan

AU - Zhang, Shanchun

AU - Li, Zhiping

AU - Tang, Gengfu

AU - Liu, Xue

AU - Yang, Jianhua

AU - Xu, Xiping

AU - Langman, Craig

AU - Wang, Xiaobin

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