Abstract
Peptides and peptidomimetics can function as immunomodulating agents by either blocking the immune response or stimulating the immune response to generate tolerance. Knowledge of B- or T-cell epitopes along with conformational constraints is important in the design of peptide-based immunomodulating agents. Work on the conformational aspects of peptides, synthesis and modified amino acid side chains have contributed to the development of a new generation of therapeutic agents for autoimmune diseases and cancer. The design of peptides/peptidomimetics for immunomodulation in autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, systemic lupus and HIV infection is reviewed. In cancer therapy, peptide epitopes are used in such a way that the body is trained to recognize and fight the cancer cells locally as well as systemically.
Original language | English (US) |
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Pages (from-to) | 755-774 |
Number of pages | 20 |
Journal | Immunotherapy |
Volume | 6 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2014 |
Externally published | Yes |
Keywords
- T-cell epitope
- cyclotide
- immunomodulation
- peptide-based vaccine
- peptidomimetics
- β-amino acid
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology