Peptides and peptidomimetics as immunomodulators

Ameya S. Gokhale, Seetharama Satyanarayanajois

Research output: Contribution to journalReview articlepeer-review

Abstract

Peptides and peptidomimetics can function as immunomodulating agents by either blocking the immune response or stimulating the immune response to generate tolerance. Knowledge of B- or T-cell epitopes along with conformational constraints is important in the design of peptide-based immunomodulating agents. Work on the conformational aspects of peptides, synthesis and modified amino acid side chains have contributed to the development of a new generation of therapeutic agents for autoimmune diseases and cancer. The design of peptides/peptidomimetics for immunomodulation in autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, systemic lupus and HIV infection is reviewed. In cancer therapy, peptide epitopes are used in such a way that the body is trained to recognize and fight the cancer cells locally as well as systemically.

Original languageEnglish (US)
Pages (from-to)755-774
Number of pages20
JournalImmunotherapy
Volume6
Issue number6
DOIs
StatePublished - Jun 2014
Externally publishedYes

Keywords

  • T-cell epitope
  • cyclotide
  • immunomodulation
  • peptide-based vaccine
  • peptidomimetics
  • β-amino acid

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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