Peptide YY: A potential proabsorptive hormone for the treatment of malabsorptive disorders

Carson D. Liu, Tom Aloia, Thomas E. Adrian, Todd R. Newton, Anton J. Bilchik, Michael J. Zinner, Stanley W. Ashley, David W. Mcfadden

Research output: Contribution to journalArticle

Abstract

Peptide YY (PYY) is a 36 amino acid peptide that is released from the endocrine cells of the distal ileum, colon, and rectum following a meal. PYY is strongly proabsorptive in the small intestine. We studied the effects of intravenous PYY on colonic water and electrolyte transport in awake dogs. Dogs had 20 cm neurovascularly intact colon Thiry-Vella fistulas (TVF) surgically constructed. Colonic transport was studied in three experimental groups. Group 1 animals received a standard mixed meal. Group 2 animals were unfed and received intravenous PYY at 100 pmol/kg/hr for two hours. This dose of PYY has previously been shown to simulate the plasma levels of PYY normally seen after a meal. Group 3 received intravenous PYY at the same dose in addition to a mixed meal. Our study shows an increase in colonic water, Na+, and Cl- absorption after a meal (P <0.05). Infusion of PYY at a 100 pmol/kg/hr was significantly proabsorptive beginning at 60 minutes (P <0.01). Infusion of PYY in addition to a meal further increased absorption (P <0.05). PYY is a potent proabsorptive agent in the colon of the conscious dog. PYY, or its analogs, may be useful clinical agents in intestinal malabsorptive disorders or after bowel resection.

Original languageEnglish (US)
Pages (from-to)232-236
Number of pages5
JournalAmerican Surgeon
Volume62
Issue number3
StatePublished - Mar 1996
Externally publishedYes

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Peptide YY
Hormones
Meals
Colon
Dogs
Endocrine Cells
Water
Ileum
Rectum
Electrolytes
Small Intestine
Fistula

ASJC Scopus subject areas

  • Surgery

Cite this

Liu, C. D., Aloia, T., Adrian, T. E., Newton, T. R., Bilchik, A. J., Zinner, M. J., ... Mcfadden, D. W. (1996). Peptide YY: A potential proabsorptive hormone for the treatment of malabsorptive disorders. American Surgeon, 62(3), 232-236.

Peptide YY : A potential proabsorptive hormone for the treatment of malabsorptive disorders. / Liu, Carson D.; Aloia, Tom; Adrian, Thomas E.; Newton, Todd R.; Bilchik, Anton J.; Zinner, Michael J.; Ashley, Stanley W.; Mcfadden, David W.

In: American Surgeon, Vol. 62, No. 3, 03.1996, p. 232-236.

Research output: Contribution to journalArticle

Liu, CD, Aloia, T, Adrian, TE, Newton, TR, Bilchik, AJ, Zinner, MJ, Ashley, SW & Mcfadden, DW 1996, 'Peptide YY: A potential proabsorptive hormone for the treatment of malabsorptive disorders', American Surgeon, vol. 62, no. 3, pp. 232-236.
Liu CD, Aloia T, Adrian TE, Newton TR, Bilchik AJ, Zinner MJ et al. Peptide YY: A potential proabsorptive hormone for the treatment of malabsorptive disorders. American Surgeon. 1996 Mar;62(3):232-236.
Liu, Carson D. ; Aloia, Tom ; Adrian, Thomas E. ; Newton, Todd R. ; Bilchik, Anton J. ; Zinner, Michael J. ; Ashley, Stanley W. ; Mcfadden, David W. / Peptide YY : A potential proabsorptive hormone for the treatment of malabsorptive disorders. In: American Surgeon. 1996 ; Vol. 62, No. 3. pp. 232-236.
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