Peptide vaccine for colorectal cancer; an update

Shoichi Hazama, Koji Yoshida, Hirokazu Shinozaki, Yuka Inoue, Yoshinari Maeda, Yoshitaro Shindo, Nobuaki Suzuki, Kiyoshi Yoshimura, Shigefumi Yoshino, Takuya Tsunoda, Hiroyuki Furukawa, Yusuke Nakamura, Masaaki Oka

Research output: Contribution to journalArticlepeer-review

Abstract

Colorectal cancer is a common disease which accounts for around half a million deaths yearly worldwide. We have performed genome-wide exploration using cDNA microarray profiling, and successfully identified a new tumor-associated antigen (TAA) that can induce potent cytotoxic T lymphocytes specific to tumor cells, ie, RNF43, KOC1, TOMM34, VEGFR1 and VEGFR2. We conducted a phase I dose escalation study and a phase II study using these five tumor-associated antigen epitope peptides for colorectal cancer patients. For a breakthrough in tumor escape mechanisms, immuno-chemo-combined therapy has been conducted. Tumor-cell killing by anticancer drugs may be attributed to their immuno- and pharmacologic effects. Chemotherapy is in fact able to upregulate tumor-associated antigen expression, and to downregulate tumor cell resistance to the death signals induced by tumor antigen-specific cytotoxic T lymphocytes. This provides the rationale for combining chemo- and immunotherapy. We conducted a phase II trial with the administration of epitope peptides alongside chemotherapy (5-fluorouracil, folinic acid, and oxaliplatin (FOLFOX)) to evaluate immunologic and clinical responses.

Original languageEnglish (US)
Pages (from-to)857-861
Number of pages5
JournalBiotherapy
Volume25
Issue number6
StatePublished - Nov 30 2011
Externally publishedYes

Keywords

  • Colorectal cancer
  • Epitope peptides
  • Vaccine

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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