Peptide T and glucose metabolism in AIDS dementia complex

Victor L. Villemagne, Robert L. Phillips, Xiang Liu, Stephen F. Gilson, Robert F. Dannals, Dean F. Wong, Pamela J. Harris, Michael Ruff, Candace Pert, Peter Bridge, Edythe D. London

Research output: Contribution to journalArticle

Abstract

AIDS dementia complex (ADC) is the most common presenting neurologic manifestation of human immunodeficiency virus (HIV)-1 infection. We report FDG-PET studies in a 39 yr-old man who had ADC and completed a 12-wk treatment protocol with 1.2 mg/day of intranasal peptide T, one before and one after 12 wk of treatment with peptide T. Peptide T is an octapeptide under investigation for treatment of ADC patients. Values of rCMRglc were converted to Z scores using the mean and standard deviation of values of rCMRglc in three HlV-seronegative matched controls, each of which was studied twice, at the beginning and end of a 12-wk interval. Thirty-five of 60 regions assayed showed Z scores with absolute values ≤3 (considered abnormal) in the baseline study. Regions with high absolute values of Z scores were located in subcortical areas and in the limbic system, and to a lesser degree in the frontal, temporal and parietal lobes. Thirty-four of these 35 regions showed remission (decrease in the absolute values of Z scores) after treatment. Only one region showed no improvement in the second study. Three regions with absolute values of Z scores <3 in the baseline study manifested Z scores with magnitudes ≤3 in the second study. These preliminary observations suggest that functional neuroimaging techniques provide a useful tool in the evaluation of the response to treatment in ADC patients.

Original languageEnglish (US)
Pages (from-to)1177-1180
Number of pages4
JournalJournal of Nuclear Medicine
Volume37
Issue number7
StatePublished - Jul 1 1996
Externally publishedYes

Keywords

  • AIDS dementia
  • brain imaging
  • glucose metabolism
  • peptide T

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Villemagne, V. L., Phillips, R. L., Liu, X., Gilson, S. F., Dannals, R. F., Wong, D. F., Harris, P. J., Ruff, M., Pert, C., Bridge, P., & London, E. D. (1996). Peptide T and glucose metabolism in AIDS dementia complex. Journal of Nuclear Medicine, 37(7), 1177-1180.