TY - JOUR
T1 - Peptide Leukotriene Release after Antigen Challenge in Patients Sensitive to Ragweed
AU - Creticos, Peter S.
AU - Peters, Stephen P.
AU - Adkinson, N. Franklin
AU - Naclerio, Robert M.
AU - Hayes, Edward C.
AU - Norman, Philip S.
AU - Lichtenstein, Lawrence M.
PY - 1984/6/21
Y1 - 1984/6/21
N2 - Slow-reacting substance of anaphylaxis (composed of leukotrienes C, D, and E) is released in vitro by the interaction of antigen and IgE antibody on human mast cells and basophils. When we challenged ragweed-sensitive patients intranasally with pollen grains, their clinical response was significantly correlated with the release of the peptide leukotrienes (P<0.001). Nonallergic subjects had neither symptoms nor leukotriene release. The leukotrienes were released in a dose-dependent fashion, with a peak mean level of 827±234 pg per 0.1 ml of a 10-ml nasal wash. High-performance liquid chromatography revealed the presence of leukotrienes C, D, and E, suggesting that nasal cells or fluids had the ability to degrade leukotriene C enzymatically. The in vivo release of these potent inflammatory mediators after exposure to pollen suggests that leukotrienes may have an important role in human allergic reactions. (N Engl J Med 1984; 310:1626–30.).
AB - Slow-reacting substance of anaphylaxis (composed of leukotrienes C, D, and E) is released in vitro by the interaction of antigen and IgE antibody on human mast cells and basophils. When we challenged ragweed-sensitive patients intranasally with pollen grains, their clinical response was significantly correlated with the release of the peptide leukotrienes (P<0.001). Nonallergic subjects had neither symptoms nor leukotriene release. The leukotrienes were released in a dose-dependent fashion, with a peak mean level of 827±234 pg per 0.1 ml of a 10-ml nasal wash. High-performance liquid chromatography revealed the presence of leukotrienes C, D, and E, suggesting that nasal cells or fluids had the ability to degrade leukotriene C enzymatically. The in vivo release of these potent inflammatory mediators after exposure to pollen suggests that leukotrienes may have an important role in human allergic reactions. (N Engl J Med 1984; 310:1626–30.).
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U2 - 10.1056/NEJM198406213102502
DO - 10.1056/NEJM198406213102502
M3 - Article
C2 - 6328300
AN - SCOPUS:0021136478
SN - 0028-4793
VL - 310
SP - 1626
EP - 1630
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 25
ER -