Peptide-based subunit vaccines against pre-erythrocytic stages of malaria parasites

Moriya Tsuji, Fidel P Zavala

Research output: Contribution to journalArticle

Abstract

Malaria currently ranks among the most prevalent infections in tropical and sub-tropical areas throughout the world with relatively high morbidity and mortality particularly in young children. The widespread occurrence and the increased incidence of malaria in many countries, caused by drug-resistant parasites (Plasmodium falciparum and P. vivax) and insecticide-resistant vectors (Anopheles mosquitoes), indicate the need to develop new methods of controlling this disease. Experimental vaccination with radiation-attenuated sporozoites can protect animals and humans against the disease, demonstrating the feasibility of developing an effective malaria vaccine. However, vaccines based on radiation-attenuated sporozoites are not feasible for large scale application due to lack of in vitro culture system. Therefore, the development of peptide-based subunit vaccines has been undertaken as an alternative approach. Synthetic peptides containing defined B- and T-cell epitopes of different antigens expressed in sporozoites and/or liver stages have been used as subunit vaccines in experimental animal models. They have been shown to be highly immunogenic and capable of inducing protective immunity mediated by antibodies, as well as CD4+ and CD8+ T-cells.

Original languageEnglish (US)
Pages (from-to)433-442
Number of pages10
JournalMolecular Immunology
Volume38
Issue number6
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Sporozoites
Subunit Vaccines
Malaria
Parasites
Peptides
Radiation
Malaria Vaccines
B-Lymphocyte Epitopes
Anopheles
T-Lymphocyte Epitopes
Plasmodium falciparum
Insecticides
Immunity
Vaccination
Vaccines
Animal Models
Morbidity
T-Lymphocytes
Antigens
Mortality

Keywords

  • Antibodies
  • Liver stages
  • Malaria
  • Sporozoite
  • Synthetic peptides
  • T-cells

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Cite this

Peptide-based subunit vaccines against pre-erythrocytic stages of malaria parasites. / Tsuji, Moriya; Zavala, Fidel P.

In: Molecular Immunology, Vol. 38, No. 6, 2001, p. 433-442.

Research output: Contribution to journalArticle

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