TY - JOUR
T1 - Peptide-based strategies for enhanced cell uptake, transcellular transport, and circulation
T2 - Mechanisms and challenges
AU - Komin, A.
AU - Russell, L. M.
AU - Hristova, K. A.
AU - Searson, P. C.
N1 - Funding Information:
The authors gratefully acknowledge support from NIH (U54CA151838 and GM68619) and NSF (MCB1157687).
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/2
Y1 - 2017/2
N2 - Peptides are emerging as a new tool in drug and gene delivery. Peptide-drug conjugates and peptide-modified drug delivery systems provide new opportunities to avoid macrophage recognition and subsequent phagocytosis, cross endothelial and epithelial barriers, and enter the cytoplasm of target cells. Peptides are relatively small, low-cost, and are stable in a wide range of biological conditions. In this review, we summarize recent work in designing peptides to enhance penetration of biological barriers, increase cell uptake, and avoid the immune system. We highlight recent successes and contradictory results, and outline common emerging concepts and design rules. The development of sequence-structure–function relationships and standard protocols for benchmarking will be a key to progress in the field.
AB - Peptides are emerging as a new tool in drug and gene delivery. Peptide-drug conjugates and peptide-modified drug delivery systems provide new opportunities to avoid macrophage recognition and subsequent phagocytosis, cross endothelial and epithelial barriers, and enter the cytoplasm of target cells. Peptides are relatively small, low-cost, and are stable in a wide range of biological conditions. In this review, we summarize recent work in designing peptides to enhance penetration of biological barriers, increase cell uptake, and avoid the immune system. We highlight recent successes and contradictory results, and outline common emerging concepts and design rules. The development of sequence-structure–function relationships and standard protocols for benchmarking will be a key to progress in the field.
KW - Cell-penetrating peptides
KW - Drug delivery
KW - Immune evasion
KW - Peptide–cell interactions
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U2 - 10.1016/j.addr.2016.06.002
DO - 10.1016/j.addr.2016.06.002
M3 - Review article
C2 - 27313077
AN - SCOPUS:84992450905
VL - 110-111
SP - 52
EP - 64
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
ER -