People with schizophrenia and depression have a low omega-3 index

Natalie Parletta, Dorota Zarnowiecki, Jihyun Cho, Amy Wilson, Nicholas Procter, Andrea Gordon, Svetlana Bogomolova, Kerin O'Dea, John Strachan, Matt Ballestrin, Andrew Champion, Barbara J. Meyer

Research output: Contribution to journalArticle

Abstract

Cardiovascular disease (CVD) is higher in people with mental illness and is associated with a 30 year higher mortality rate in this population. Erythrocyte docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (omega-3 index)≤4% is a marker for increased mortality risk from CVD while >8% is protective. Omega-3 polyunsaturated fatty acids are also important for brain function and may ameliorate symptoms of mental illness. We investigated the erythrocyte omega-3 index in people with mental illness. One hundred and thirty adults aged 18-65 years (32.6% male) with schizophrenia (n=14) and depression (n=116) provided blood samples and completed physiological assessments and questionnaires. Both populations had risk factors for metabolic syndrome and CVD. The average omega-3 index was 3.95% (SD=1.06), compared to an estimated 5% in the Australian population. These data indicate an unfavourable omega-3 profile in people with mental illness that could contribute to higher CVD risk.

Original languageEnglish (US)
Pages (from-to)42-47
Number of pages6
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume110
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

Fingerprint

Schizophrenia
Cardiovascular Diseases
Depression
Erythrocytes
Population
Eicosapentaenoic Acid
Mortality
Docosahexaenoic Acids
Metabolic Diseases
Omega-3 Fatty Acids
Unsaturated Fatty Acids
Brain
Blood

Keywords

  • Cardiovascular disease
  • Depression
  • Mental illness
  • Omega-3
  • Omega-3 index
  • Polyunsaturated fatty acids
  • Schizophrenia

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

Cite this

Parletta, N., Zarnowiecki, D., Cho, J., Wilson, A., Procter, N., Gordon, A., ... Meyer, B. J. (2016). People with schizophrenia and depression have a low omega-3 index. Prostaglandins Leukotrienes and Essential Fatty Acids, 110, 42-47. https://doi.org/10.1016/j.plefa.2016.05.007

People with schizophrenia and depression have a low omega-3 index. / Parletta, Natalie; Zarnowiecki, Dorota; Cho, Jihyun; Wilson, Amy; Procter, Nicholas; Gordon, Andrea; Bogomolova, Svetlana; O'Dea, Kerin; Strachan, John; Ballestrin, Matt; Champion, Andrew; Meyer, Barbara J.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 110, 01.07.2016, p. 42-47.

Research output: Contribution to journalArticle

Parletta, N, Zarnowiecki, D, Cho, J, Wilson, A, Procter, N, Gordon, A, Bogomolova, S, O'Dea, K, Strachan, J, Ballestrin, M, Champion, A & Meyer, BJ 2016, 'People with schizophrenia and depression have a low omega-3 index', Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 110, pp. 42-47. https://doi.org/10.1016/j.plefa.2016.05.007
Parletta, Natalie ; Zarnowiecki, Dorota ; Cho, Jihyun ; Wilson, Amy ; Procter, Nicholas ; Gordon, Andrea ; Bogomolova, Svetlana ; O'Dea, Kerin ; Strachan, John ; Ballestrin, Matt ; Champion, Andrew ; Meyer, Barbara J. / People with schizophrenia and depression have a low omega-3 index. In: Prostaglandins Leukotrienes and Essential Fatty Acids. 2016 ; Vol. 110. pp. 42-47.
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