People with schizophrenia and depression have a low omega-3 index

Natalie Parletta, Dorota Zarnowiecki, Jihyun Cho, Amy Wilson, Nicholas Procter, Andrea Gordon, Svetlana Bogomolova, Kerin O'Dea, John Strachan, Matt Ballestrin, Andrew Champion, Barbara J. Meyer

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiovascular disease (CVD) is higher in people with mental illness and is associated with a 30 year higher mortality rate in this population. Erythrocyte docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (omega-3 index)≤4% is a marker for increased mortality risk from CVD while >8% is protective. Omega-3 polyunsaturated fatty acids are also important for brain function and may ameliorate symptoms of mental illness. We investigated the erythrocyte omega-3 index in people with mental illness. One hundred and thirty adults aged 18-65 years (32.6% male) with schizophrenia (n=14) and depression (n=116) provided blood samples and completed physiological assessments and questionnaires. Both populations had risk factors for metabolic syndrome and CVD. The average omega-3 index was 3.95% (SD=1.06), compared to an estimated 5% in the Australian population. These data indicate an unfavourable omega-3 profile in people with mental illness that could contribute to higher CVD risk.

Original languageEnglish (US)
Pages (from-to)42-47
Number of pages6
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume110
DOIs
StatePublished - Jul 1 2016

Keywords

  • Cardiovascular disease
  • Depression
  • Mental illness
  • Omega-3
  • Omega-3 index
  • Polyunsaturated fatty acids
  • Schizophrenia

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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