Pentoxifylline inhibits Ig κ gene transcription and rearrangements in Pre-B cells

Weihong Wang, Satyajit Rath, Jeannine M. Durdik, Ranjan Sen

Research output: Contribution to journalArticle

Abstract

Pentoxifylline (PF) has been used in a wide variety of clinical situations; however, the molecular consequences of this drug are not well characterized. In this paper we assayed the effects of PF in two models of pre-B differentiation. In 70Z pre-B cells, transcriptional induction of rearranged Ig κ-chain gene in response to LPS was suppressed by PF, without affecting the induction of Rel family proteins. In contrast, κ induction by IFN-γ was not suppressed by PF, indicating that the drug inhibited certain activation pathways. We also found that LPS-induced activation of germline κ transcription and Vκ to Jκ recombination were inhibited by PF in the pre-B cell line 38B9. These observations suggest that PF may adversely affect B lymphopoiesis during chronic administration.

Original languageEnglish (US)
Pages (from-to)1789-1795
Number of pages7
JournalJournal of Immunology
Volume160
Issue number4
StatePublished - Feb 15 1998
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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  • Cite this

    Wang, W., Rath, S., Durdik, J. M., & Sen, R. (1998). Pentoxifylline inhibits Ig κ gene transcription and rearrangements in Pre-B cells. Journal of Immunology, 160(4), 1789-1795.