Pentoxifylline attenuates edema formation in proteolytic enzyme-induced lung injury

B. A. Rosenfeld, T. J.K. Toung, M. J. Sendak, M. J. Breslow, G. M. Hutchins, R. J. Traystman

Research output: Contribution to journalArticlepeer-review

Abstract

Ex vivo canine lung lobes were exposed to a pancreatic proteolytic enzyme (chymotrypsin) alone or chymotrypsin after pretreatment with a continuous infusion with pentoxifylline. The lobes exposed to chymotrypsin gained 133 g, while the pentoxifylline-treated lobes gained only 65 g (p < .05) over the 3-h experimental period. These results suggest that pentoxifylline significantly attenuates the lung weight gain associated with chymotrypsin.

Original languageEnglish (US)
Pages (from-to)1394-1397
Number of pages4
JournalCritical care medicine
Volume18
Issue number12
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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