Abstract
Ex vivo canine lung lobes were exposed to a pancreatic proteolytic enzyme (chymotrypsin) alone or chymotrypsin after pretreatment with a continuous infusion with pentoxifylline. The lobes exposed to chymotrypsin gained 133 g, while the pentoxifylline-treated lobes gained only 65 g (p < .05) over the 3-h experimental period. These results suggest that pentoxifylline significantly attenuates the lung weight gain associated with chymotrypsin.
Original language | English (US) |
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Pages (from-to) | 1394-1397 |
Number of pages | 4 |
Journal | Critical care medicine |
Volume | 18 |
Issue number | 12 |
DOIs | |
State | Published - Jan 1 1990 |
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine