Pentostatin for the treatment of chronic graft-versus-host disease in children

Jenna D. Goldberg, David A. Jacobsohn, Jeffrey Margolis, Allen R. Chen, Viki Anders, Michele Phelps, Georgia B. Vogelsang

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic graft-versus-host disease (cGVHD) is a major barrier to successful allogeneic stem cell transplantation. Pentostatin has been used to treat cGVHD in a small series of pediatric patients. The authors report the results of the first five pediatric patients receiving pentostatin for refractory cGVHD at Johns Hopkins Hospital. In this early experience, the authors saw considerable symptom response in their patients. Every patient in this series demonstrated a significant improvement in skin and oral symptoms. An increased incidence of infection secondary to pentostatin was not observed. No patient was permanently discontinued from pentostatin subsequent to side effects. If these promising results continue, a trial of pentostatin as a first-line therapy for cGVHD should be considered to potentially reduce our dependence on high-dose steroids for its treatment.

Original languageEnglish (US)
Pages (from-to)584-588
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Volume25
Issue number7
DOIs
StatePublished - Jul 1 2003

Keywords

  • Bone marrow transplant
  • Graft-versus-host disease
  • Pentostatin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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