Pentobarbital Anesthesia Reduces Blood–Brain Glucose Transfer in the Rat

Albert Gjedde, Mette Rasmussen

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract: Pentobarbital anesthesia (40 mg kg–1) was accompanied by a 50% decrease of blood flow and a 40% decrease of unidirectional blood‐brain glucose transfer in the parietal cortex of the rat brain. The correlation was explained by a decrease of the number of perfused capillaries. The maximal transport capacity, Tmax, decreased from 409 to 235 μ mol 100 g–1 min–1 and the half‐saturation constant, Km, from 8.8 to 4.9 mm. At 8.3–8.7 mm‐glucose in arterial plasma, the transfer constant (clearance) for unidirectional blood‐brain transfer decreased from 0.195 ± 0.011 in awake rats to 0.132 ± 0.005 ml g–1 min–1 in anesthetized rats. Half of the decrease was due to less complete diffusion‐limitation of glucose uptake at the low plasma flow rate in brain, the other half to the decreased Tmax.

Original languageEnglish (US)
Pages (from-to)1382-1387
Number of pages6
JournalJournal of Neurochemistry
Volume35
Issue number6
DOIs
StatePublished - Dec 1980

Keywords

  • Blood‐brain barrier
  • Blood‐brain glucose transfer
  • Pentobarbital anesthesia

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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