Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat

A. Gjedde, M. Rasmussen

Research output: Contribution to journalArticle

Abstract

Pentobarbital anesthesia (40 mg kg-1) was accompanied by a 50% decrease of blood flow and a 40% decrease of unidirectional blood-brain glucose transfer in the parietal cortex of the rat brain. The correlation was explained by a decrease of the number of perfused capillaries. The maximal transport capacity, T(max), decreased from 409 to 235 μmol 100 g-1 min-1 and the half-saturation constant, K(m) from 8.8 to 4.9 mM. At 8.3-8.7 mM-glucose in arterial plasma, the transfer constant (clearance) for unidirectional r313w9 =accomplished blood-brain transfer decreased from 0.195 ± 0.011 in awake rats to 0.132 ± 0.005 ml g-1 min-1 in anesthetized rats. Half of the decrase was due to less complete diffusion-limitation of glucose uptake at the low plasma flow rate in brain, the other half to the decreased T(max).

Original languageEnglish (US)
Pages (from-to)1382-1387
Number of pages6
JournalJournal of Neurochemistry
Volume35
Issue number6
StatePublished - 1980
Externally publishedYes

Fingerprint

Pentobarbital
Blood Glucose
Rats
Brain
Blood
Anesthesia
Glucose
Plasma flow
Parietal Lobe
Flow rate
Plasmas

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat. / Gjedde, A.; Rasmussen, M.

In: Journal of Neurochemistry, Vol. 35, No. 6, 1980, p. 1382-1387.

Research output: Contribution to journalArticle

Gjedde, A & Rasmussen, M 1980, 'Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat', Journal of Neurochemistry, vol. 35, no. 6, pp. 1382-1387.
Gjedde, A. ; Rasmussen, M. / Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat. In: Journal of Neurochemistry. 1980 ; Vol. 35, No. 6. pp. 1382-1387.
@article{ae5a70cf9bac4ce1bb05b4505fc3ea9e,
title = "Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat",
abstract = "Pentobarbital anesthesia (40 mg kg-1) was accompanied by a 50{\%} decrease of blood flow and a 40{\%} decrease of unidirectional blood-brain glucose transfer in the parietal cortex of the rat brain. The correlation was explained by a decrease of the number of perfused capillaries. The maximal transport capacity, T(max), decreased from 409 to 235 μmol 100 g-1 min-1 and the half-saturation constant, K(m) from 8.8 to 4.9 mM. At 8.3-8.7 mM-glucose in arterial plasma, the transfer constant (clearance) for unidirectional r313w9 =accomplished blood-brain transfer decreased from 0.195 ± 0.011 in awake rats to 0.132 ± 0.005 ml g-1 min-1 in anesthetized rats. Half of the decrase was due to less complete diffusion-limitation of glucose uptake at the low plasma flow rate in brain, the other half to the decreased T(max).",
author = "A. Gjedde and M. Rasmussen",
year = "1980",
language = "English (US)",
volume = "35",
pages = "1382--1387",
journal = "Journal of Neurochemistry",
issn = "0022-3042",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Pentobarbital anesthesia reduces blood-brain glucose transfer in the rat

AU - Gjedde, A.

AU - Rasmussen, M.

PY - 1980

Y1 - 1980

N2 - Pentobarbital anesthesia (40 mg kg-1) was accompanied by a 50% decrease of blood flow and a 40% decrease of unidirectional blood-brain glucose transfer in the parietal cortex of the rat brain. The correlation was explained by a decrease of the number of perfused capillaries. The maximal transport capacity, T(max), decreased from 409 to 235 μmol 100 g-1 min-1 and the half-saturation constant, K(m) from 8.8 to 4.9 mM. At 8.3-8.7 mM-glucose in arterial plasma, the transfer constant (clearance) for unidirectional r313w9 =accomplished blood-brain transfer decreased from 0.195 ± 0.011 in awake rats to 0.132 ± 0.005 ml g-1 min-1 in anesthetized rats. Half of the decrase was due to less complete diffusion-limitation of glucose uptake at the low plasma flow rate in brain, the other half to the decreased T(max).

AB - Pentobarbital anesthesia (40 mg kg-1) was accompanied by a 50% decrease of blood flow and a 40% decrease of unidirectional blood-brain glucose transfer in the parietal cortex of the rat brain. The correlation was explained by a decrease of the number of perfused capillaries. The maximal transport capacity, T(max), decreased from 409 to 235 μmol 100 g-1 min-1 and the half-saturation constant, K(m) from 8.8 to 4.9 mM. At 8.3-8.7 mM-glucose in arterial plasma, the transfer constant (clearance) for unidirectional r313w9 =accomplished blood-brain transfer decreased from 0.195 ± 0.011 in awake rats to 0.132 ± 0.005 ml g-1 min-1 in anesthetized rats. Half of the decrase was due to less complete diffusion-limitation of glucose uptake at the low plasma flow rate in brain, the other half to the decreased T(max).

UR - http://www.scopus.com/inward/record.url?scp=0019132998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019132998&partnerID=8YFLogxK

M3 - Article

C2 - 7441256

AN - SCOPUS:0019132998

VL - 35

SP - 1382

EP - 1387

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

SN - 0022-3042

IS - 6

ER -