Penile transplantation

The US experience and institutional program set-up

April Adams Szafran, Richard Redett, Arthur Burnett

Research output: Contribution to journalReview article

Abstract

Penile transplantation using vascularized composite allografts is an emerging technique to treat genital loss. In the United States, this procedure has been performed successfully at Massachusetts General Hospital in a patient who had previously undergone treatment for penile cancer. The Johns Hopkins Medical Institutions has developed a research protocol to perform penile transplantation in patients with genital loss secondary to trauma. The process of selecting the appropriate candidate for genitourinary (GU) vascularized composite allograft surgery is rigorous including extensive physical examination, laboratory testing, imaging and psychological evaluations. After transplantation, limiting the potential complications associated with immunosuppression is critical given that the procedure is intended to improve quality of life and is not life-saving. Ultimately, penile transplant is a surgical intervention which may have numerous applications. Optimization of the pre-operative screening process, surgical technique, and immunosuppressive protocol is required to establish this method as the standard treatment for patients with genital loss and limited reconstructive options.

Original languageEnglish (US)
Pages (from-to)639-645
Number of pages7
JournalTranslational Andrology and Urology
Volume7
Issue number4
DOIs
StatePublished - May 1 2018

Fingerprint

Composite Tissue Allografts
Transplantation
Penile Neoplasms
Immunosuppressive Agents
General Hospitals
Immunosuppression
Physical Examination
Quality of Life
Psychology
Transplants
Therapeutics
Research

Keywords

  • Allotransplantation
  • Genitourinary (GU)
  • Neophalloplasty

ASJC Scopus subject areas

  • Reproductive Medicine
  • Urology

Cite this

Penile transplantation : The US experience and institutional program set-up. / Szafran, April Adams; Redett, Richard; Burnett, Arthur.

In: Translational Andrology and Urology, Vol. 7, No. 4, 01.05.2018, p. 639-645.

Research output: Contribution to journalReview article

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