Penicillamine-Induced Pemphigus: Immunoglobulin From This Patient Induces Plasminogen Activator Synthesis by Human Epidermal Cells in Culture: Mechanism for Acantholysis in Pemphigus

Koji Hashimoto, Kay Singer, Gerald S. Lazarus

Research output: Contribution to journalArticlepeer-review

Abstract

The incubation of cultured epidermal cells with IgG obtained from a 56-year-old man with penicillamine-induced pemphigus resulted in an increase in extracellular and intracellular plasminogen activator. This suggests that penicillamine-induced pemphigus and spontaneously occurring pemphigus share common pathophysiologic processes in the induction of blister formation.

Original languageEnglish (US)
Pages (from-to)762-764
Number of pages3
JournalArchives of dermatology
Volume120
Issue number6
DOIs
StatePublished - Jun 1984
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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