Penicillamine-Induced Pemphigus: Immunoglobulin From This Patient Induces Plasminogen Activator Synthesis by Human Epidermal Cells in Culture: Mechanism for Acantholysis in Pemphigus

Koji Hashimoto; Kay Singer; Gerald S. Lazarus

doi:10.1001/archderm.120.6.762

Penicillamine-Induced Pemphigus: Immunoglobulin From This Patient Induces Plasminogen Activator Synthesis by Human Epidermal Cells in Culture: Mechanism for Acantholysis in Pemphigus

Koji Hashimoto, Kay Singer, Gerald S. Lazarus

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The incubation of cultured epidermal cells with IgG obtained from a 56-year-old man with penicillamine-induced pemphigus resulted in an increase in extracellular and intracellular plasminogen activator. This suggests that penicillamine-induced pemphigus and spontaneously occurring pemphigus share common pathophysiologic processes in the induction of blister formation.

Original language	English (US)
Pages (from-to)	762-764
Number of pages	3
Journal	Archives of Dermatology
Volume	120
Issue number	6
DOIs	https://doi.org/10.1001/archderm.120.6.762
State	Published - Jun 1984
Externally published	Yes

ASJC Scopus subject areas

Dermatology

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title = "Penicillamine-Induced Pemphigus: Immunoglobulin From This Patient Induces Plasminogen Activator Synthesis by Human Epidermal Cells in Culture: Mechanism for Acantholysis in Pemphigus",

abstract = "The incubation of cultured epidermal cells with IgG obtained from a 56-year-old man with penicillamine-induced pemphigus resulted in an increase in extracellular and intracellular plasminogen activator. This suggests that penicillamine-induced pemphigus and spontaneously occurring pemphigus share common pathophysiologic processes in the induction of blister formation.",

author = "Koji Hashimoto and Kay Singer and Lazarus, {Gerald S.}",

year = "1984",

month = jun,

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AU - Hashimoto, Koji

AU - Singer, Kay

AU - Lazarus, Gerald S.

PY - 1984/6

Y1 - 1984/6

N2 - The incubation of cultured epidermal cells with IgG obtained from a 56-year-old man with penicillamine-induced pemphigus resulted in an increase in extracellular and intracellular plasminogen activator. This suggests that penicillamine-induced pemphigus and spontaneously occurring pemphigus share common pathophysiologic processes in the induction of blister formation.

AB - The incubation of cultured epidermal cells with IgG obtained from a 56-year-old man with penicillamine-induced pemphigus resulted in an increase in extracellular and intracellular plasminogen activator. This suggests that penicillamine-induced pemphigus and spontaneously occurring pemphigus share common pathophysiologic processes in the induction of blister formation.

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Penicillamine-Induced Pemphigus: Immunoglobulin From This Patient Induces Plasminogen Activator Synthesis by Human Epidermal Cells in Culture: Mechanism for Acantholysis in Pemphigus

Abstract

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