Penetration of topical 0.3% ciprofloxacin into human aqueous humor

Defne Kalayci; Nursabah Basci; Esen Akpek; Hikmet Hasiripi; Atilla Bozkurt

Penetration of topical 0.3% ciprofloxacin into human aqueous humor

Defne Kalayci, Nursabah Basci, Esen Akpek, Hikmet Hasiripi, Atilla Bozkurt

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND AND OBJECTIVE: Investigation of the penetration of topical ciprofloxacin into aqueous humor. PATIENTS AND METHODS: Topical 0.3% ciprofloxacin drops were administered to 17 patients with cataracts before lens extraction surgery. The time interval between the first dose and sampling was 3 hours in 9 patients (group A) and 6 hours in 8 (group B). In both groups, aqueous samples were collected 30 minutes after the last ciprofloxacin application. Ciprofloxacin concentration was determined by high-performance liquid chromatography-fluorescence detection. RESULTS: Mean aqueous concentration was 0.83 ± 0.48 μg/ml in group A and 2.42 ± 1.42 μg/ml in group B. CONCLUSION: Topical 0.3% ciprofloxacin penetrates into the aqueous in a significant concentration.

Original language	English (US)
Pages (from-to)	21-24
Number of pages	4
Journal	Ophthalmic Surgery and Lasers
Volume	27
Issue number	1
State	Published - Jan 1 1996
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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title = "Penetration of topical 0.3% ciprofloxacin into human aqueous humor",

abstract = "BACKGROUND AND OBJECTIVE: Investigation of the penetration of topical ciprofloxacin into aqueous humor. PATIENTS AND METHODS: Topical 0.3% ciprofloxacin drops were administered to 17 patients with cataracts before lens extraction surgery. The time interval between the first dose and sampling was 3 hours in 9 patients (group A) and 6 hours in 8 (group B). In both groups, aqueous samples were collected 30 minutes after the last ciprofloxacin application. Ciprofloxacin concentration was determined by high-performance liquid chromatography-fluorescence detection. RESULTS: Mean aqueous concentration was 0.83 ± 0.48 μg/ml in group A and 2.42 ± 1.42 μg/ml in group B. CONCLUSION: Topical 0.3% ciprofloxacin penetrates into the aqueous in a significant concentration.",

author = "Defne Kalayci and Nursabah Basci and Esen Akpek and Hikmet Hasiripi and Atilla Bozkurt",

year = "1996",

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T1 - Penetration of topical 0.3% ciprofloxacin into human aqueous humor

AU - Kalayci, Defne

AU - Basci, Nursabah

AU - Akpek, Esen

AU - Hasiripi, Hikmet

AU - Bozkurt, Atilla

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N2 - BACKGROUND AND OBJECTIVE: Investigation of the penetration of topical ciprofloxacin into aqueous humor. PATIENTS AND METHODS: Topical 0.3% ciprofloxacin drops were administered to 17 patients with cataracts before lens extraction surgery. The time interval between the first dose and sampling was 3 hours in 9 patients (group A) and 6 hours in 8 (group B). In both groups, aqueous samples were collected 30 minutes after the last ciprofloxacin application. Ciprofloxacin concentration was determined by high-performance liquid chromatography-fluorescence detection. RESULTS: Mean aqueous concentration was 0.83 ± 0.48 μg/ml in group A and 2.42 ± 1.42 μg/ml in group B. CONCLUSION: Topical 0.3% ciprofloxacin penetrates into the aqueous in a significant concentration.

AB - BACKGROUND AND OBJECTIVE: Investigation of the penetration of topical ciprofloxacin into aqueous humor. PATIENTS AND METHODS: Topical 0.3% ciprofloxacin drops were administered to 17 patients with cataracts before lens extraction surgery. The time interval between the first dose and sampling was 3 hours in 9 patients (group A) and 6 hours in 8 (group B). In both groups, aqueous samples were collected 30 minutes after the last ciprofloxacin application. Ciprofloxacin concentration was determined by high-performance liquid chromatography-fluorescence detection. RESULTS: Mean aqueous concentration was 0.83 ± 0.48 μg/ml in group A and 2.42 ± 1.42 μg/ml in group B. CONCLUSION: Topical 0.3% ciprofloxacin penetrates into the aqueous in a significant concentration.

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