Penetration of topical 0.3% ciprofloxacin into human aqueous humor

Defne Kalayci, Nursabah Basci, Esen Akpek, Hikmet Hasiripi, Atilla Bozkurt

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND AND OBJECTIVE: Investigation of the penetration of topical ciprofloxacin into aqueous humor. PATIENTS AND METHODS: Topical 0.3% ciprofloxacin drops were administered to 17 patients with cataracts before lens extraction surgery. The time interval between the first dose and sampling was 3 hours in 9 patients (group A) and 6 hours in 8 (group B). In both groups, aqueous samples were collected 30 minutes after the last ciprofloxacin application. Ciprofloxacin concentration was determined by high-performance liquid chromatography-fluorescence detection. RESULTS: Mean aqueous concentration was 0.83 ± 0.48 μg/ml in group A and 2.42 ± 1.42 μg/ml in group B. CONCLUSION: Topical 0.3% ciprofloxacin penetrates into the aqueous in a significant concentration.

Original languageEnglish (US)
Pages (from-to)21-24
Number of pages4
JournalOphthalmic Surgery and Lasers
Volume27
Issue number1
StatePublished - Jan 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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