Penetration of SCH-39304, a new antifungal triazole into cerebrospinal fluid of primates

T. J. Walsh, C. Lester-McCully, M. G. Rinaldi, J. E. Wallace, F. M. Balis, J. W. Lee, P. A. Pizzo, D. G. Poplack

Research output: Contribution to journalArticle

Abstract

We characterize the cerebrospinal fluid (CSF) penetration and pharmacokinetics of SCH-39304 in adult rhesus monkeys receiving a single oral dose of SCH-39304 (2.0 mg/kg of body weight). The mean CSF-to-lasma area under the curve ratio was 0.63 (± 0.18, standard error of the mean); maximum concentrations were 1.34 μg/ml (± 0.18) in CSF and 1.96 μg/ml (± 0.43) in plasma. The mean plasma half-life was 45.7 (± 0.3) in plasma and 0.96 μg/ml (± 0.12) in CSF. We conclude that SCH-39304 effectively penetrates into CSF and achieves concentrations considered active against many opportunistic yeast and that these concentrations are sustained in CSF for ≥ 24 h.

Original languageEnglish (US)
Pages (from-to)1281-1284
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume34
Issue number6
StatePublished - 1990
Externally publishedYes

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Triazoles
Primates
Cerebrospinal Fluid
Macaca mulatta
Area Under Curve
Half-Life
Pharmacokinetics
Yeasts
Body Weight

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Walsh, T. J., Lester-McCully, C., Rinaldi, M. G., Wallace, J. E., Balis, F. M., Lee, J. W., ... Poplack, D. G. (1990). Penetration of SCH-39304, a new antifungal triazole into cerebrospinal fluid of primates. Antimicrobial Agents and Chemotherapy, 34(6), 1281-1284.

Penetration of SCH-39304, a new antifungal triazole into cerebrospinal fluid of primates. / Walsh, T. J.; Lester-McCully, C.; Rinaldi, M. G.; Wallace, J. E.; Balis, F. M.; Lee, J. W.; Pizzo, P. A.; Poplack, D. G.

In: Antimicrobial Agents and Chemotherapy, Vol. 34, No. 6, 1990, p. 1281-1284.

Research output: Contribution to journalArticle

Walsh, TJ, Lester-McCully, C, Rinaldi, MG, Wallace, JE, Balis, FM, Lee, JW, Pizzo, PA & Poplack, DG 1990, 'Penetration of SCH-39304, a new antifungal triazole into cerebrospinal fluid of primates', Antimicrobial Agents and Chemotherapy, vol. 34, no. 6, pp. 1281-1284.
Walsh TJ, Lester-McCully C, Rinaldi MG, Wallace JE, Balis FM, Lee JW et al. Penetration of SCH-39304, a new antifungal triazole into cerebrospinal fluid of primates. Antimicrobial Agents and Chemotherapy. 1990;34(6):1281-1284.
Walsh, T. J. ; Lester-McCully, C. ; Rinaldi, M. G. ; Wallace, J. E. ; Balis, F. M. ; Lee, J. W. ; Pizzo, P. A. ; Poplack, D. G. / Penetration of SCH-39304, a new antifungal triazole into cerebrospinal fluid of primates. In: Antimicrobial Agents and Chemotherapy. 1990 ; Vol. 34, No. 6. pp. 1281-1284.
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