Penetration of SCH-39304, a new antifungal triazole into cerebrospinal fluid of primates

T. J. Walsh, C. Lester-McCully, M. G. Rinaldi, J. E. Wallace, F. M. Balis, J. W. Lee, P. A. Pizzo, D. G. Poplack

Research output: Contribution to journalArticle

Abstract

We characterize the cerebrospinal fluid (CSF) penetration and pharmacokinetics of SCH-39304 in adult rhesus monkeys receiving a single oral dose of SCH-39304 (2.0 mg/kg of body weight). The mean CSF-to-lasma area under the curve ratio was 0.63 (± 0.18, standard error of the mean); maximum concentrations were 1.34 μg/ml (± 0.18) in CSF and 1.96 μg/ml (± 0.43) in plasma. The mean plasma half-life was 45.7 (± 0.3) in plasma and 0.96 μg/ml (± 0.12) in CSF. We conclude that SCH-39304 effectively penetrates into CSF and achieves concentrations considered active against many opportunistic yeast and that these concentrations are sustained in CSF for ≥ 24 h.

Original languageEnglish (US)
Pages (from-to)1281-1284
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume34
Issue number6
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Walsh, T. J., Lester-McCully, C., Rinaldi, M. G., Wallace, J. E., Balis, F. M., Lee, J. W., Pizzo, P. A., & Poplack, D. G. (1990). Penetration of SCH-39304, a new antifungal triazole into cerebrospinal fluid of primates. Antimicrobial agents and chemotherapy, 34(6), 1281-1284. https://doi.org/10.1128/AAC.34.6.1281