Abstract
The surface modification of drug/gene delivery vehicles with polyethylene glycol (PEG) to improve intracellular transport of drug/gene carries was analzyed using real-time particle tracking. Diamine PEG was attached to 100 nm carboxylated polystyrene particles (PS) using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDAC) chemistry. PEGylated particles displayed diffusivities statistically greater than unmodified particles at the time scale of 1 s. The results show that PEGylation of nanoparticles improves their cytoplasmic transport rates possibly by reducing non-specific adhesion to cytoskeletal elements.
| Original language | English (US) |
|---|---|
| Pages | 1313 |
| Number of pages | 1 |
| State | Published - 2004 |
| Event | 2004 AIChE Annual Meeting - Austin, TX, United States Duration: Nov 7 2004 → Nov 12 2004 |
Other
| Other | 2004 AIChE Annual Meeting |
|---|---|
| Country/Territory | United States |
| City | Austin, TX |
| Period | 11/7/04 → 11/12/04 |
ASJC Scopus subject areas
- General Engineering