PEG improves intracellular transport of drug/gene carriers as revealed by real-time particle tracking

K. Choy, J. Suh, J. Hanes

Research output: Contribution to conferencePaper

Abstract

The surface modification of drug/gene delivery vehicles with polyethylene glycol (PEG) to improve intracellular transport of drug/gene carries was analzyed using real-time particle tracking. Diamine PEG was attached to 100 nm carboxylated polystyrene particles (PS) using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDAC) chemistry. PEGylated particles displayed diffusivities statistically greater than unmodified particles at the time scale of 1 s. The results show that PEGylation of nanoparticles improves their cytoplasmic transport rates possibly by reducing non-specific adhesion to cytoskeletal elements.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 2004
Event2004 AIChE Annual Meeting - Austin, TX, United States
Duration: Nov 7 2004Nov 12 2004

Other

Other2004 AIChE Annual Meeting
CountryUnited States
CityAustin, TX
Period11/7/0411/12/04

ASJC Scopus subject areas

  • Engineering(all)

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    Choy, K., Suh, J., & Hanes, J. (2004). PEG improves intracellular transport of drug/gene carriers as revealed by real-time particle tracking. Paper presented at 2004 AIChE Annual Meeting, Austin, TX, United States.