TY - JOUR
T1 - Peeking into the black box
T2 - New biomarkers for acute kidney injury
AU - Thurman, J. M.
AU - Parikh, C. R.
PY - 2008/2
Y1 - 2008/2
N2 - The development of effective therapies for acute kidney injury (AKI) has been hindered by delayed diagnosis in the clinical setting, varying definitions of AKI, and limited prognostic information. In a study by Portilla et al., elevations in liver fatty acid-binding protein (L-FABP) were found to predict AKI in children undergoing cardiac surgery. New biomarkers offer the promise of earlier and more accurate diagnosis of AKI. Before they can be deemed clinically useful, however, they must undergo rigorous validation in multiple cohorts.
AB - The development of effective therapies for acute kidney injury (AKI) has been hindered by delayed diagnosis in the clinical setting, varying definitions of AKI, and limited prognostic information. In a study by Portilla et al., elevations in liver fatty acid-binding protein (L-FABP) were found to predict AKI in children undergoing cardiac surgery. New biomarkers offer the promise of earlier and more accurate diagnosis of AKI. Before they can be deemed clinically useful, however, they must undergo rigorous validation in multiple cohorts.
UR - http://www.scopus.com/inward/record.url?scp=38749134500&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38749134500&partnerID=8YFLogxK
U2 - 10.1038/sj.ki.5002739
DO - 10.1038/sj.ki.5002739
M3 - Comment/debate
C2 - 18235520
AN - SCOPUS:38749134500
SN - 0085-2538
VL - 73
SP - 379
EP - 381
JO - Kidney international
JF - Kidney international
IS - 4
ER -