Pedigree study of familial alzheimer disease

Diane Powell, Marshal F. Folstein

Research output: Contribution to journalArticle

Abstract

Twenty-one families with familial Alzheimer disease were ascertained in a dementia clinic and assessed by multiple family interviews. Eight autopsies were reviewed. The age of onset varied from 25 to 85. Seven pedigrees showed evidence of 3 generation transmission. Paternal age of the founders of 4 lines which could be assessed was higher than controls.

Original languageEnglish (US)
Pages (from-to)189-197
Number of pages9
JournalJournal of Neurogenetics
Volume1
Issue number2
DOIs
StatePublished - 1984

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Paternal Age
Pedigree
Age of Onset
Dementia
Autopsy
Alzheimer Disease
Interviews

Keywords

  • Alzheimer disease
  • Pedigree study

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Genetics
  • Developmental Biology
  • Neuroscience(all)

Cite this

Pedigree study of familial alzheimer disease. / Powell, Diane; Folstein, Marshal F.

In: Journal of Neurogenetics, Vol. 1, No. 2, 1984, p. 189-197.

Research output: Contribution to journalArticle

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