Pedigree study of familial alzheimer disease

Diane Powell; Marshal F. Folstein

doi:10.3109/01677068409107085

Pedigree study of familial alzheimer disease

Diane Powell, Marshal F. Folstein

School of Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Twenty-one families with familial Alzheimer disease were ascertained in a dementia clinic and assessed by multiple family interviews. Eight autopsies were reviewed. The age of onset varied from 25 to 85. Seven pedigrees showed evidence of 3 generation transmission. Paternal age of the founders of 4 lines which could be assessed was higher than controls.

Original language	English (US)
Pages (from-to)	189-197
Number of pages	9
Journal	Journal of Neurogenetics
Volume	1
Issue number	2
DOIs	https://doi.org/10.3109/01677068409107085
State	Published - 1984

Keywords

Alzheimer disease
Pedigree study

ASJC Scopus subject areas

Genetics
Cellular and Molecular Neuroscience

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10.3109/01677068409107085

Cite this

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title = "Pedigree study of familial alzheimer disease",

abstract = "Twenty-one families with familial Alzheimer disease were ascertained in a dementia clinic and assessed by multiple family interviews. Eight autopsies were reviewed. The age of onset varied from 25 to 85. Seven pedigrees showed evidence of 3 generation transmission. Paternal age of the founders of 4 lines which could be assessed was higher than controls.",

keywords = "Alzheimer disease, Pedigree study",

author = "Diane Powell and Folstein, {Marshal F.}",

note = "Funding Information: Dr. Helen Abbey was of great assistance in the statistical analysis. Supported in part by T. Rowe and Eleanor Price Teaching Service and NS-16375.",

year = "1984",

doi = "10.3109/01677068409107085",

language = "English (US)",

volume = "1",

pages = "189--197",

journal = "Journal of Neurogenetics",

issn = "0167-7063",

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T1 - Pedigree study of familial alzheimer disease

AU - Powell, Diane

AU - Folstein, Marshal F.

N1 - Funding Information: Dr. Helen Abbey was of great assistance in the statistical analysis. Supported in part by T. Rowe and Eleanor Price Teaching Service and NS-16375.

PY - 1984

Y1 - 1984

N2 - Twenty-one families with familial Alzheimer disease were ascertained in a dementia clinic and assessed by multiple family interviews. Eight autopsies were reviewed. The age of onset varied from 25 to 85. Seven pedigrees showed evidence of 3 generation transmission. Paternal age of the founders of 4 lines which could be assessed was higher than controls.

AB - Twenty-one families with familial Alzheimer disease were ascertained in a dementia clinic and assessed by multiple family interviews. Eight autopsies were reviewed. The age of onset varied from 25 to 85. Seven pedigrees showed evidence of 3 generation transmission. Paternal age of the founders of 4 lines which could be assessed was higher than controls.

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KW - Pedigree study

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JO - Journal of Neurogenetics

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Pedigree study of familial alzheimer disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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