Pedigree study of familial alzheimer disease

Diane Powell, Marshal F. Folstein

Research output: Contribution to journalArticle

Abstract

Twenty-one families with familial Alzheimer disease were ascertained in a dementia clinic and assessed by multiple family interviews. Eight autopsies were reviewed. The age of onset varied from 25 to 85. Seven pedigrees showed evidence of 3 generation transmission. Paternal age of the founders of 4 lines which could be assessed was higher than controls.

Original languageEnglish (US)
Pages (from-to)189-197
Number of pages9
JournalJournal of Neurogenetics
Volume1
Issue number2
DOIs
StatePublished - Jan 1 1984

Keywords

  • Alzheimer disease
  • Pedigree study

ASJC Scopus subject areas

  • Genetics
  • Cellular and Molecular Neuroscience

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