Pedigree analysis of blood pressure in subjects from rural Greece and relatives who migrated to Melbourne, Australia

John L. Hopper, Greg T. Macaskill, John W. Powles, Dimitri Ktenas, Aravinda Chakravarti

Research output: Contribution to journalArticlepeer-review

Abstract

Diastolic blood pressure readings taken in 1983–1984 on 1,474 Greek individuals (628 living on the island of Levkada, 846 relatives having migrated to Melbourne, Australia) from 204 two generational pedigrees were analysed. Blood pressure was regressed as a quadratic in age by sex and migrant status, and on temperature. Variance increased with age and was greater in migrant males. The covariance between relatives in different countries was significant. Variation was modeled by a multivariate normal model for pedigree analysis in terms of genetic effects, a common environment effect, and effects particular to an individual. The genetic component was 25.9 mm Hg2, independent of sex and migrant status. Importantly, the common environment component was not significant. The third component was greatest in migrant males. Spouse correlation was −0.09 (SE = 0.03). Exclusion of 86 individuals who reported currently receiving medication for elevated blood pressure stabilised the variance and decreased the genetic component. The data suggest that familial aggregation of diasatolic blood pressure is due to genetic factors which produce the same variation in males and females, living on Levkada or in Melbourne. Nongenetic factors explain the greater variation in blood pressure of migrant males living in Melbourne. © 1992 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)225-238
Number of pages14
JournalGenetic epidemiology
Volume9
Issue number4
DOIs
StatePublished - 1992

Keywords

  • diastolic blood pressure
  • familial aggregation
  • genetic factors
  • heritability
  • migrants
  • pedigree analysis
  • variance components

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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