Pediatric rhabdomyosarcoma of the head and neck

Dennis H. Kraus, Nicholas C. Saenz, Smitha Gollamudi, Glenn Heller, Margarita Moustakis, Sharon Gardiner, William L. Gerald, Fereshteh Ghavimi, Michael P. LaQuaglia

Research output: Contribution to journalArticle

Abstract

PURPOSE: Survival for pediatric rhabdomyosarcoma has improved with the use of multidrug chemotherapy and external beam radiotherapy. This study was performed to determine survival in a cohort of patients treated on one of three multidrug treatment protocols for head and neck rhabdomyosarcoma and to identify factors that place patients at risk for treatment failure. METHODS: Pertinent prognostic variables including age, sex, subsite of origin, resectability, and TNM stage were analyzed by the Kaplan-Meier methods with comparisons between variables performed using the Prentice-Wilcoxon test statistic. RESULTS: Overall 5-year survival was 74% (95% confidence interval 64% to 84%). Local failure accounted for the cause of death in 10 patients, and 8 died of disseminated disease. On univariate analysis, each variable contributing to the TNM staging system was significant in determining survival; invasiveness (P = 0.01), size (P = 0.02), nodal metastases (P <0.01), and distant disease (P <0.01). CONCLUSION: Survival has improved for head and neck rhabdomyosarcoma treated with multimodality therapy. Patients with advanced-stage disease are at greatest risk for treatment failure and require the most aggressive therapy.

Original languageEnglish (US)
Pages (from-to)556-560
Number of pages5
JournalAmerican journal of surgery
Volume174
Issue number5
DOIs
StatePublished - Nov 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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    Kraus, D. H., Saenz, N. C., Gollamudi, S., Heller, G., Moustakis, M., Gardiner, S., Gerald, W. L., Ghavimi, F., & LaQuaglia, M. P. (1997). Pediatric rhabdomyosarcoma of the head and neck. American journal of surgery, 174(5), 556-560. https://doi.org/10.1016/S0002-9610(97)00171-2