Abstract
Advancements in donor management, organ preservation and operative techniques, as well as immunosuppressive therapies, have provided children with intestinal failure and its complications a chance not only for enteral autonomy but also long-term survival through intestinal transplantation (ITx). First described in the 1960’s, experience has grown in managing these complex patients both pre- and post-transplant. The goals of this review are to provide a brief history of intestinal transplantation and intestinal rehabilitation in pediatric patients, followed by focused discussions of the indications for ITx, induction and maintenance immunosuppression therapies, common post-operative complications, and outcomes/quality of life post-transplant.
Original language | English (US) |
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Article number | 151181 |
Journal | Seminars in pediatric surgery |
Volume | 31 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2022 |
Keywords
- Immunosuppression
- Infection
- Intestinal failure
- Intestinal transplant
- Post-transplant lymphoproliferative disease
- Post-transplant outcomes
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Surgery