Pediatric high-grade glioma: Clinical-, treatment-related, and biologic prognostic factors

Russell K. Hales, Moody D. Wharam

Research output: Contribution to journalReview article


Brain tumors are the most common solid tumors in children and gliomas are the most common subtype. Despite their relative frequency, malignant gliomas have a 10-fold lower incidence in children compared to adults. As a result, prognostic variables in adults are extrapolated to pediatric patients for treatment decision making and patient counseling. In this review, we outline the known clinical- and treatmentrelated factors associated with outcome in pediatric high-grade glioma (HGG). We define the limitations of using adult HGG to drive pediatric HGG decision making by showing a unique molecular signature and oncogenic pathway in pediatric HGG that is distinct from adult HGG. Biologic determinants of prognosis are reviewed.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalEuropean journal of Clinical and Medical Oncology
Issue number3
StatePublished - Dec 1 2012


  • Astrocytoma
  • Biomarkers
  • Glioma
  • Malignant
  • Pediatric
  • Prognosis

ASJC Scopus subject areas

  • Oncology

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